Substrate-bound structures of a ketoreductase from amphotericin modular polyketide synthase.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of structural biology"
DOI: 10.1016/j.jsb.2018.04.001
Abstract: Ketoreductase (KR) domains of modular polyketide synthases (PKSs) control the stereochemistry of C2 methyl and C3 hydroxyl substituents of polyketide intermediates. To understand the molecular basis of stereocontrol exerted by KRs, the crystal structure of… read more here.
Keywords: polyketide; structures ketoreductase; bound structures; substrate bound ... See more keywords
Alternative substrate-bound conformation of bacterial solute-binding protein involved in the import of mammalian host glycosaminoglycans
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.2210/pdb5xs8/pdb
Abstract: Glycosaminoglycans (GAGs), constituted by repeating uronate and amino sugar units, are major components of mammalian extracellular matrices. Some indigenous and pathogenic bacteria target GAGs for colonization to and/or infection of host mammalian cells. In Gram-negative… read more here.
Keywords: substrate bound; solute binding; bound; binding protein ... See more keywords