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Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b03850
Abstract: A Lewis-acid-catalyzed method for the substrate-directed formation of peptide bonds has been developed, and this powerful approach is utilized for the new "remote" activation of carboxyl groups under solvent-free conditions. The presented method has the…
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Keywords:
lewis acid;
synthesis;
substrate directed;
peptide synthesis ... See more keywords
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Published in 2020 at "Organic chemistry frontiers"
DOI: 10.1039/c9qo01436e
Abstract: Highly chemo- and regioselective substrate-directed benzannulation of trisubstituted CF3-alkenes and 2-benzylidenemalononitriles or 2-nitroallylic acetates has been achieved via Michael-initiated [4 + 2] or Rauhut–Currier-initiated [3 + 3] annulation. These protocols enable the rapid assembly of…
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Keywords:
synthesis polyfunctionalized;
chemo regioselective;
substrate directed;
directed chemo ... See more keywords
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Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc02686d
Abstract: Herein, we report a substrate-directed diverse synthetic strategy toward two kinds of structurally intriguing fused indole polycycles through Rh(II)-catalyzed cascade reactions of bis(diazo)indolin-2-ones with enaminones. The subtle structural changes in enaminones lead to different reactivities.…
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Keywords:
substrate directed;
catalyzed cascade;
fused indole;
cascade reactions ... See more keywords