Substrate Directed Regio‐ and Enantioselective Ring‐Opening of Epoxides and Aziridines
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DOI: 10.1002/cctc.202301431
Abstract: The oxirane and aziridine rings are valuable building blocks in modern synthetic chemistry and catalytic asymmetric ring opening reactions of these three membered ring systems have emerged as a powerful chemical tool for the synthesis… read more here.
Keywords: regio enantioselective; ring opening; epoxides aziridines; substrate directed ... See more keywords
Substrate-Directed Lewis-Acid Catalysis for Peptide Synthesis.
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DOI: 10.1021/jacs.9b03850
Abstract: A Lewis-acid-catalyzed method for the substrate-directed formation of peptide bonds has been developed, and this powerful approach is utilized for the new "remote" activation of carboxyl groups under solvent-free conditions. The presented method has the… read more here.
Keywords: lewis acid; synthesis; substrate directed; peptide synthesis ... See more keywords
Substrate-directed chemo- and regioselective synthesis of polyfunctionalized trifluoromethylarenes via organocatalytic benzannulation
Sign Up to like & getrecommendations! Published in 2020 at "Organic chemistry frontiers"
DOI: 10.1039/c9qo01436e
Abstract: Highly chemo- and regioselective substrate-directed benzannulation of trisubstituted CF3-alkenes and 2-benzylidenemalononitriles or 2-nitroallylic acetates has been achieved via Michael-initiated [4 + 2] or Rauhut–Currier-initiated [3 + 3] annulation. These protocols enable the rapid assembly of… read more here.
Keywords: synthesis polyfunctionalized; chemo regioselective; substrate directed; directed chemo ... See more keywords
Substrate-directed divergent synthesis of fused indole polycycles through Rh(II)-catalyzed cascade reactions of bis(diazo)indolin-2-ones.
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DOI: 10.1039/d2cc02686d
Abstract: Herein, we report a substrate-directed diverse synthetic strategy toward two kinds of structurally intriguing fused indole polycycles through Rh(II)-catalyzed cascade reactions of bis(diazo)indolin-2-ones with enaminones. The subtle structural changes in enaminones lead to different reactivities.… read more here.
Keywords: substrate directed; catalyzed cascade; fused indole; cascade reactions ... See more keywords
Substrate-directed novel direct amidation of resin-bound amino acids
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DOI: 10.1093/chemle/upae107
Abstract: In peptide drug discovery, the C-terminal structure of peptide compounds is crucial for enhancing the affinity with target proteins and for optimizing the compound's dynamics and physical properties. In conventional solid-phase synthesis, two steps are… read more here.
Keywords: direct amidation; directed novel; novel direct; substrate directed ... See more keywords