Heterogeneity in winged helix‐turn‐helix and substrate DNA interactions: Insights from theory and experiments
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30369
Abstract: Specific interactions between transcription factors (TFs) and substrate DNA constitute the fundamental basis of gene expression. Unlike in TFs like basic helix‐loop‐helix or basic leucine zippers, prediction of substrate DNA is extremely challenging for helix‐turn‐helix… read more here.
Keywords: heterogeneity; helix turn; dna; substrate dna ... See more keywords
Mechanism for APOBEC3G catalytic exclusion of RNA and non-substrate DNA
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz550
Abstract: Abstract The potent antiretroviral protein APOBEC3G (A3G) specifically targets and deaminates deoxycytidine nucleotides, generating deoxyuridine, in single stranded DNA (ssDNA) intermediates produced during HIV replication. A non-catalytic domain in A3G binds strongly to RNA, an… read more here.
Keywords: non substrate; mechanism apobec3g; rna; substrate dna ... See more keywords