Substrate Engagement and Catalytic Mechanisms of N-Acetylglucosaminyltransferase V
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DOI: 10.1021/acscatal.0c02222
Abstract: α-Mannoside β-1,6-N-acetylglucosaminyltransferase V (MGAT5) is a mammalian glycosyltransferase involved in complex N-glycan formation, which strongly drives cancer when overexpressed. Despite intense interest, the catalytic mechanism of MGAT5 is not known in detail, precluding therapeutic exploitation.… read more here.
Keywords: mgat5; engagement catalytic; catalytic mechanisms; mechanisms acetylglucosaminyltransferase ... See more keywords
Activation-induced substrate engagement in ERK signaling
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DOI: 10.1091/mbc.e19-07-0355
Abstract: The extracellular signal-regulated kinase (ERK) pathway is an essential component of developmental signaling in metazoans. Previous models of pathway activation suggested that dissociation of activated dually phosphorylated ERK (dpERK) from MAPK/ERK kinase (MEK), a kinase… read more here.
Keywords: cic; activation induced; induced substrate; erk ... See more keywords