Theory on the rate equation of Michaelis–Menten type single-substrate enzyme catalyzed reactions
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Mathematical Chemistry"
DOI: 10.1007/s10910-017-0791-3
Abstract: Analytical solution to the Michaelis–Menten (MM) rate equations for single-substrate enzyme catalysed reaction is not known. Here we introduce an effective scaling scheme and identify the critical parameters which can completely characterize the entire dynamics… read more here.
Keywords: single substrate; steady state; substrate product; substrate ... See more keywords
Tetraterpene Synthase Substrate and Product Specificity in the Green Microalga Botryococcus braunii Race L.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.7b00457
Abstract: Recently, the biosynthetic pathway for lycopadiene, a C40 tetraterpenoid hydrocarbon, was deciphered from the L race of Botryococcus braunii, an alga that produces hydrocarbon oils capable of being converted into combustible fuels. The lycopadiene pathway… read more here.
Keywords: product specificity; synthase; los; substrate product ... See more keywords
Substrate and product binding inside a stimuli-responsive coordination cage acting as a singlet oxygen photosensitizer.
Sign Up to like & getrecommendations! Published in 2020 at "Dalton transactions"
DOI: 10.1039/d0dt01674h
Abstract: An acridone-based, interpenetrated double cage [3BF4Pd4L8] acts as a photosensitizer for generating singlet oxygen which adds to 1,3-cyclohexadiene in a [2+4] hetero-Diels-Alder reaction to form 2,3-dioxabicyclo[2.2.2]oct-5-ene. Photocatalytic activity was exclusively observed for the assembled cage,… read more here.
Keywords: singlet oxygen; cage; substrate product;
PyMiner: A method for metabolic pathway design based on the uniform similarity of substrate-product pairs and conditional search
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0266783
Abstract: Metabolic pathway design is an essential step in the course of constructing an efficient microbial cell factory to produce high value-added chemicals. Meanwhile, the computational design of biologically meaningful metabolic pathways has been attracting much… read more here.
Keywords: metabolic pathway; pathway design; substrate product; design ... See more keywords
Native to designed: microbial -amylases for industrial applications
Sign Up to like & getrecommendations! Published in 2021 at "PeerJ"
DOI: 10.7717/peerj.11315
Abstract: Background -amylases catalyze the endo-hydrolysis of -1,4-D-glycosidic bonds in starch into smaller moieties. While industrial processes are usually performed at harsh conditions, -amylases from mainly the bacteria, fungi and yeasts are preferred for their stabilities… read more here.
Keywords: engineering; microbial amylases; protein engineering; substrate product ... See more keywords