Probing functional interactions between cytochromes P450 with principal component analysis of substrate saturation profiles and targeted proteomics.
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DOI: 10.1016/j.abb.2021.108937
Abstract: We investigated the correspondence between drug metabolism routes and the composition of the P450 ensemble in human liver microsomes (HLM). As a probe, we used Coumarin 152 (C152), a fluorogenic substrate metabolized by multiple P450… read more here.
Keywords: principal component; analysis; targeted proteomics; substrate saturation ... See more keywords