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   Articles with "substrate selectivity" as a keyword



Repurposing a bacterial prolidase for organophosphorus hydrolysis: reshaped catalytic cavity switches substrate selectivity.

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recommendations! Published in 2020 at "Biotechnology and bioengineering"

DOI: 10.1002/bit.27455

Abstract: Enzyme promiscuity is critical to the acquisition of evolutionary plasticity in cells and can be recruited for high-value chemical synthesis or xenobiotic degradation. The molecular determinants of substrate ambiguity are essential to this activity; however,… read more here.

Keywords: substrate selectivity; repurposing bacterial; hydrolysis; bacterial prolidase ... See more keywords

A variable loop involved in the substrate selectivity of pinoresinol/lariciresinol reductase from Camellia sinensis.

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recommendations! Published in 2019 at "Phytochemistry"

DOI: 10.1016/j.phytochem.2019.02.003

Abstract: Pinoresinol/lariciresinol reductase (PLR), an NADPH-dependent reductase that catalyzes the sequential reduction of pinoresinol into secoisolariciresinol via Lariciresinol, can lead to the structural and stereochemical diversity of lignans. The relationship between substrate-selective reaction of PLR and… read more here.

Keywords: pinoresinol lariciresinol; sinensis; reductase; substrate selectivity ... See more keywords
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Structural basis of substrate selectivity of viperin.

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recommendations! Published in 2020 at "Biochemistry"

DOI: 10.1021/acs.biochem.9b00741

Abstract: Viperin is a radical S-adenosylmethionine (SAM) enzyme that inhibits viral replication by converting cytidine triphosphate (CTP) into 3-deoxy-3,4-didehydro-CTP and by additional undefined mechanisms operating through its N- and C-terminal domains. Here, we describe crystal structures… read more here.

Keywords: basis substrate; structural basis; ctp utp; substrate selectivity ... See more keywords

Structure-Based Pocket Modification to Regulate Substrate Selectivity of a Novel Fatty Acid Photodecarboxylase from Chrysochromulina tobinii.

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recommendations! Published in 2025 at "Journal of agricultural and food chemistry"

DOI: 10.1021/acs.jafc.5c05074

Abstract: Fatty acid photodecarboxylases (FAPs) are promising biocatalysts for converting renewable fatty acids into alkanes. However, naturally occurring FAPs capable of catalyzing aromatic acids are exceedingly rare. In this study, we engineered the substrate selectivity of… read more here.

Keywords: structure; substrate selectivity; pocket; selectivity ... See more keywords

Promiscuity and Quantitative Contribution of UGT2B17 in Drug and Steroid Metabolism Determined by Experimental and Computational Approaches

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recommendations! Published in 2024 at "Journal of chemical information and modeling"

DOI: 10.1021/acs.jcim.3c01514

Abstract: Uridine 5'-diphospho-glulcuronosyltransferase 2B17 (UGT2B17) is important in the metabolism of steroids and orally administered drugs due to its high interindividual variability. However, the structural basis governing the substrate selectivity or inhibition of UGT2B17 remains poorly… read more here.

Keywords: contribution ugt2b17; promiscuity quantitative; quantitative contribution; substrate selectivity ... See more keywords

A Host-Guest Approach to Engineering Oxidase-Mimetic Assembly with Substrate Selectivity and Dynamic Catalysis.

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recommendations! Published in 2024 at "ACS applied materials & interfaces"

DOI: 10.1021/acsami.4c08030

Abstract: The creation of synthetic materials that emulate the complexity of natural systems, such as enzymes, remains a challenge in biomimicry. Here, we present a simple yet effective strategy to introduce substrate selectivity and dynamic responsiveness… read more here.

Keywords: oxidase; substrate selectivity; selectivity dynamic; selectivity ... See more keywords

A Membrane-Embedded Macromolecular Catalyst with Substrate Selectivity in Live Cells.

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recommendations! Published in 2022 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.2c11168

Abstract: Substrate selectivity is one of the most attractive features of natural enzymes from their "bind-to-catalyze" working flow and is thus a goal for the development of synthetic enzyme mimics that mediate abiotic transformations. However, despite… read more here.

Keywords: substrate selectivity; selectivity; macromolecular catalyst; membrane ... See more keywords

Substrate-Selectivity in Catalytic Photooxygenation Processes Using a Quinine-BODIPY System

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recommendations! Published in 2020 at "Synlett"

DOI: 10.1055/s-0039-1690796

Abstract: Substrate selectivity by means of synthetic catalysts remains a challenging topic in chemistry. Here, a catalytic system combining an iodo-BODIPY photosensitizer and quinine was evaluated in the competitive photooxygenation of non-hydrogen and hydrogen-bond-donor substrates. The… read more here.

Keywords: selectivity catalytic; system; photooxygenation; substrate selectivity ... See more keywords

Identification of Molecular Determinants in iRhoms1 and 2 That Contribute to the Substrate Selectivity of Stimulated ADAM17

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms232112796

Abstract: The metalloprotease ADAM17 is a key regulator of the TNFα, IL-6R and EGFR signaling pathways. The maturation and function of ADAM17 is controlled by the seven-membrane-spanning proteins iRhoms1 and 2. The functional properties of the… read more here.

Keywords: adam17; stimulated shedding; substrate selectivity; shedding adam17 ... See more keywords