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Published in 2017 at "ACS Catalysis"
DOI: 10.1021/acscatal.7b02634
Abstract: Prediction of substrate-specific mutational hotspots for enzyme engineering is a complex and computationally intensive task. This becomes particularly challenging when the available crystal structures have no ligand, bind a distant homologue of the desired substrate,…
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Keywords:
screening mutational;
molecular dynamics;
mutational hotspots;
ligand ... See more keywords
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Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14804
Abstract: Membrane proteins play vital roles in inside-out and outside-in signal transduction by responding to inputs that include mechanical stimuli. Mechanical gating may be mediated by the membrane or by protein(s) but evidence for the latter…
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Keywords:
dependent transporters;
tonb dependent;
specific forced;
transporters substrate ... See more keywords