Sex-Specific Response to Combinations of Shear Stress and Substrate Stiffness by Endothelial Cells In Vitro.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202100735
Abstract: By using a full factorial design of experiment, the combinatorial effects of biological sex, shear stress, and substrate stiffness on human umbilical vein endothelial cell (HUVEC) spreading and Yes-associated protein 1 (YAP1) activity are able… read more here.
Keywords: stress substrate; sex; shear stress; substrate stiffness ... See more keywords
Regulating chondrocyte senescence through substrate stiffness modulation
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Applied Polymer Science"
DOI: 10.1002/app.56032
Abstract: Chondrocytes, the resident cells of articular cartilage, play a vital role in tissue maintenance and regeneration. Recent studies have highlighted chondrocyte senescence as a key contributor to cartilage dysfunction. In this study, we investigated the… read more here.
Keywords: senescence; chondrocyte senescence; regulating chondrocyte; substrate stiffness ... See more keywords
Gene expression profiling of human hepatocytes grown on differing substrate stiffness
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology Letters"
DOI: 10.1007/s10529-018-2536-1
Abstract: ObjectiveTo study the effects of different substrate stiffness on human hepatocytes using RNA sequencing (RNA-Seq) technology. The stiffness was corresponding to physiology and pathology stiffness of liver tissues.ResultsWith the aid of RNA-Seq technology, our study… read more here.
Keywords: stiffness; substrate stiffness; pathology; rna seq ... See more keywords
Substrate stiffness modulates the multipotency of human neural crest derived ectomesenchymal stem cells via CD44 mediated PDGFR signaling.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2018.03.022
Abstract: Mesenchymal stem cells (MSCs) have been isolated from various mesodermal and ectodermal tissues. While the phenotypic and functional heterogeneity of MSCs stemming from their developmental origins has been acknowledged, the genetic and environmental factors underpinning… read more here.
Keywords: human neural; substrate stiffness; neural crest; stem ... See more keywords
RNA-seq reveals diverse effects of substrate stiffness on mesenchymal stem cells.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2018.07.039
Abstract: Substrate stiffness has been recognized as an important regulator of cell fate and function, but an understanding of the full extent of processes affected by stiffness is lacking as its transcriptome-wide effects have not been… read more here.
Keywords: substrate stiffness; seq reveals; rna seq; stem cells ... See more keywords
Substrate stiffness induces neutrophil extracellular trap (NET) formation through focal adhesion kinase activation.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2021.120715
Abstract: Neutrophils predominate the early inflammatory response to tissue injury and implantation of biomaterials. Recent studies have shown that neutrophil activation can be regulated by mechanical cues such as stiffness or surface wettability; however, it is… read more here.
Keywords: neutrophil extracellular; substrate stiffness; formation; activation ... See more keywords
Insensitivity of dental pulp stem cells migration to substrate stiffness.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2021.120969
Abstract: Dental pulp stem cells (DPSCs) are a promising cell source for regeneration of dental pulp. Migration is a key event but influence of the microenvironment rigidity (5 kPa at the center of dental pulp to 20 GPa… read more here.
Keywords: substrate stiffness; migration; dental pulp;
Non-muscle myosin II isoforms orchestrate substrate stiffness sensing to promote cancer cell contractility and migration.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.10.030
Abstract: The stiffening of the extracellular matrix (ECM) during tumor progression results in an increase in cancer cell motility. In cell migration, two major isoforms of non-muscle myosin II (NMII), NMIIA and NMIIB, are expressed and… read more here.
Keywords: substrate stiffness; non muscle; cancer cell; cancer ... See more keywords
Exploration of the Effects of Substrate Stiffness on Biological Responses of Neural Cells and Their Mechanisms
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DOI: 10.1021/acsomega.0c04279
Abstract: Substrate stiffness, as a critical mechanical factor, has been proven to be an important regulator of biological responses, cellular functions, and disease occurrence. However, the effects of substrate stiffness on the phenotypes and drug responses… read more here.
Keywords: substrate stiffness; drug; responses neural; biological responses ... See more keywords
The impact of substrate stiffness on morphological, transcriptional and functional aspects in RPE
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DOI: 10.1038/s41598-024-56661-7
Abstract: Alterations in the structure and composition of Bruch’s membrane (BrM) and loss of retinal pigment epithelial (RPE) cells are associated with various ocular diseases, notably age-related macular degeneration (AMD) as well as several inherited retinal… read more here.
Keywords: differentially expressed; document; substrate stiffness; culture ... See more keywords
Substrate stiffness affects the immunosuppressive and trophic function of hMSCs via modulating cytoskeletal polymerization and tension.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials science"
DOI: 10.1039/c9bm01202h
Abstract: Mesenchymal stem cells (MSCs) have broad therapeutic potential due to their ability to secrete bioactive factors that are immunomodulatory and trophic (regenerative). In this study, polyacrylamide (PAAm) hydrogels with different stiffness are used as a… read more here.
Keywords: stiffness; function hmscs; immunosuppressive trophic; substrate stiffness ... See more keywords