Disordered Substrates of the 20S Proteasome Link Degradation with Phase Separation
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DOI: 10.1002/pmic.201800276
Abstract: The 20S proteasome is known to degrade intrinsically disordered proteins (IDPs) via an ubiquitin‐independent, disorder‐driven mechanism. Unless protected within protein complexes or macromolecular assemblies, certain IDPs can undergo degradation mediated directly by the 20S core… read more here.
Keywords: degradation; phase; substrates 20s; 20s proteasome ... See more keywords