Pallidal versus subthalamic nucleus deep brain stimulation for levodopa‐induced dyskinesia
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DOI: 10.1002/acn3.50961
Abstract: To compare the efficacy of subthalamic nucleus (STN) and globus pallidus internus (GPi) deep brain stimulation (DBS) on reducing levodopa‐induced dyskinesia (LID) in Parkinson’s disease, and to explore the potential underlying mechanisms. read more here.
Keywords: deep brain; levodopa induced; subthalamic nucleus; induced dyskinesia ... See more keywords
Impulsivity is associated with firing regularity in parkinsonian ventral subthalamic nucleus
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51530
Abstract: Impulsive–compulsive behaviors (ICB) are over‐represented in Parkinson's disease (PD) patients. Neurons in the ventral subthalamic nucleus (STN) might play a predominant role in the modulation of impulsivity. We characterized the firing regularity of 742 subthalamic… read more here.
Keywords: ventral subthalamic; firing regularity; impulsivity; subthalamic nucleus ... See more keywords
Subthalamic nucleus deep brain stimulation is neuroprotective in the A53T α‐synuclein Parkinson's disease rat model
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Neurology"
DOI: 10.1002/ana.24947
Abstract: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a highly effective symptomatic therapy for motor deficits in Parkinson's disease (PD). An additional, disease‐modifying effect has been suspected from studies in toxin‐based PD animal… read more here.
Keywords: deep brain; disease; parkinson disease; subthalamic nucleus ... See more keywords
Mouse subthalamic nucleus neurons with local axon collaterals
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24334
Abstract: The neuronal population of the subthalamic nucleus (STN) has the ability to prolong incoming cortical excitation. This could result from intra‐STN feedback excitation. The combination of inducible genetic fate mapping techniques with in vitro targeted… read more here.
Keywords: local axon; stn neurons; subthalamic nucleus; axon ... See more keywords
GABAA and GABAB receptor subunit localization on neurochemically identified neurons of the human subthalamic nucleus
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24368
Abstract: The subthalamic nucleus (STN) is a critical excitatory signaling center within the basal ganglia circuitry. The activity of subthalamic neurons is tightly controlled by upstream inhibitory signaling centers in the basal ganglia. In this study,… read more here.
Keywords: subthalamic nucleus; gabaa gabab; receptor subunits; receptor ... See more keywords
Subthalamic nucleus volumes are highly consistent but decrease age‐dependently—a combined magnetic resonance imaging and stereology approach in humans
Sign Up to like & getrecommendations! Published in 2017 at "Human Brain Mapping"
DOI: 10.1002/hbm.23427
Abstract: The subthalamic nucleus (STN) is a main target structure of deep brain stimulation (DBS) in idiopathic Parkinson's disease. Nevertheless, there is an ongoing discussion regarding human STN volumes and neuron count, which could potentially have… read more here.
Keywords: stereology; age; stn; combined magnetic ... See more keywords
Electrical activation of the pedunculopontine tegmental nucleus modulates the neuronal activities of the subthalamic nucleus and the substantia nigra pars reticulata in anesthetized rats
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25117
Abstract: The subthalamic nucleus (STN), substantia nigra pars reticulata (SNr), and pedunculopontine tegmental nucleus (PPTg) are reciprocally connected brain regions that play significant roles in the motor control. However, the electrophysiological relationship among the STN, SNr,… read more here.
Keywords: subthalamic nucleus; substantia nigra; stn snr; pptg ... See more keywords
Morbidity Milestones Demonstrate Long Disability‐Free Survival in Parkinson's Disease Patients with Deep Brain Stimulation of the Subthalamic Nucleus
Sign Up to like & getrecommendations! Published in 2023 at "Movement Disorders Clinical Practice"
DOI: 10.1002/mdc3.13698
Abstract: Deep brain stimulation of the subthalamic nucleus (STN‐DBS) is an effective treatment for Parkinson's disease (PD). The long‐term benefit in PD patients with STN‐DBS in comparison to medical treatment (MT) alone has not yet been… read more here.
Keywords: stimulation subthalamic; subthalamic nucleus; parkinson disease; deep brain ... See more keywords
The Contribution of Subthalamic Nucleus Deep Brain Stimulation to the Improvement in Motor Functions and Quality of Life
Sign Up to like & getrecommendations! Published in 2022 at "Movement Disorders"
DOI: 10.1002/mds.28952
Abstract: Subthalamic nucleus deep brain stimulation (STN‐DBS) effectively treats motor symptoms and quality of life (QoL) of advanced and fluctuating early Parkinson's disease. Little is known about the relation between electrode position and changes in symptom… read more here.
Keywords: subthalamic nucleus; nucleus deep; deep brain; brain stimulation ... See more keywords
Cortical and Subthalamic Nucleus Spectral Changes During Limb Movements in Parkinson's Disease Patients with and Without Dystonia
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DOI: 10.1002/mds.29057
Abstract: Dystonia is an understudied motor feature of Parkinson's disease (PD). Although considerable efforts have focused on brain oscillations related to the cardinal symptoms of PD, whether dystonia is associated with specific electrophysiological features is unclear. read more here.
Keywords: nucleus spectral; spectral changes; subthalamic nucleus; disease ... See more keywords
Chemogenetic modulation reveals distinct roles of the subthalamic nucleus and its afferents in the regulation of locomotor sensitization to amphetamine in rats.
Sign Up to like & getrecommendations! Published in 2021 at "Psychopharmacology"
DOI: 10.1007/s00213-021-05985-7
Abstract: The subthalamic nucleus (STN) is a key node in cortico-basal-ganglia thalamic circuits, guiding behavioral output through its position as an excitatory relay of the striatal indirect pathway and its direct connections with the cortex. There… read more here.
Keywords: stn; amphetamine sensitization; sensitization; subthalamic nucleus ... See more keywords