Subtle Chemical Changes Cross the Boundary between Agonist and Antagonist: New A3 Adenosine Receptor Homology Models and Structural Network Analysis Can Predict This Boundary.
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DOI: 10.1021/acs.jmedchem.1c00239
Abstract: Distinguishing compounds' agonistic or antagonistic behavior would be of great utility for the rational discovery of selective modulators. We synthesized truncated nucleoside derivatives and discovered 6c (Ki = 2.40 nM) as a potent human A3… read more here.
Keywords: subtle chemical; agonist; adenosine receptor; homology models ... See more keywords