Identification of microRNAs involved in pathways which characterize the expression subtypes of NSCLC
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12571
Abstract: Dysregulation of microRNAs is a common mechanism in the development of lung cancer, but the relationship between microRNAs and expression subtypes in non‐small‐cell lung cancer (NSCLC) is poorly explored. Here, we analyzed microRNA expression from… read more here.
Keywords: subtype specific; expression; expression subtypes; lung cancer ... See more keywords
Subtype‐specific epidemiology of lymphoid malignancies in Taiwan compared to Japan and the United States, 2002‐2012
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1762
Abstract: There are many unrevealed parts regarding lymphoma etiology. Previous studies suggested differences in lymphoma epidemiology among countries existed; however, some were one‐center studies that were not enough to represent the whole population. read more here.
Keywords: specific epidemiology; epidemiology lymphoid; subtype specific; malignancies taiwan ... See more keywords
Implementing subtype‐specific pre‐clinical models of breast cancer to study pre‐treatment aspirin effects
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4756
Abstract: Prior data suggest pre‐diagnostic aspirin use impacts breast tumour biology and patient outcome. Here, we employed faithful surgical resection models of HER2+ and triple‐negative breast cancer (TNBC), to study outcome and response mechanisms across breast… read more here.
Keywords: specific pre; implementing subtype; subtype specific; breast cancer ... See more keywords
Neuroligins Differentially Mediate Subtype-Specific Synapse Formation in Pyramidal Neurons and Interneurons
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Bulletin"
DOI: 10.1007/s12264-019-00347-y
Abstract: Neuroligins (NLs) are postsynaptic cell-adhesion proteins that play important roles in synapse formation and the excitatory-inhibitory balance. They have been associated with autism in both human genetic and animal model studies, and affect synaptic connections… read more here.
Keywords: subtype specific; pyramidal neurons; synapse formation; formation ... See more keywords
Deep-sequencing reveals broad subtype-specific HCV resistance mutations associated with treatment failure.
Sign Up to like & getrecommendations! Published in 2019 at "Antiviral research"
DOI: 10.1016/j.antiviral.2019.104694
Abstract: A percentage of hepatitis C virus (HCV)-infected patients fail direct acting antiviral (DAA)-based treatment regimens, often because of drug resistance-associated substitutions (RAS). The aim of this study was to characterize the resistance profile of a… read more here.
Keywords: subtype specific; treatment; hcv; resistance ... See more keywords
RNA-seq based transcriptome analysis of EHMT2 functions in breast cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.01.128
Abstract: For breast cancer treatment, hormone therapy is effective for hormone receptor-positive breast cancer but not for TNBC (triple-negative breast cancer). Thus, many researchers have attempted to identify more effective therapeutic candidates for all subtypes of… read more here.
Keywords: subtype specific; analysis; breast cancer; seq based ... See more keywords
Astrocyte subtype-specific approach to Alzheimer's disease treatment
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2021.104956
Abstract: Astrocytes respond to any pathological condition in the central nervous system (CNS) including Alzheimer's disease (AD), and this response is called astrocyte reactivity. Astrocyte reaction to a CNS insult is a highly heterogeneous phenomenon in… read more here.
Keywords: subtype specific; alzheimer disease; astrocyte; approach ... See more keywords
Induction of dopaminergic neurons for neuronal subtype-specific modeling of psychiatric disease risk
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Psychiatry"
DOI: 10.1038/s41380-021-01273-0
Abstract: Dopaminergic neurons are critical to movement, mood, addiction, and stress. Current techniques for generating dopaminergic neurons from human induced pluripotent stem cells (hiPSCs) yield heterogenous cell populations with variable purity and inconsistent reproducibility between donors,… read more here.
Keywords: subtype specific; psychiatric disease; dopaminergic neurons; neuronal subtype ... See more keywords
Disease and subtype specific signatures enable precise diagnosis of the mucopolysaccharidoses
Sign Up to like & getrecommendations! Published in 2018 at "Genetics in Medicine"
DOI: 10.1038/s41436-018-0136-z
Abstract: PurposeExpanding treatments for the mucopolysaccharidoses—a family of genetic disorders—place unprecedented demands for accurate, timely diagnosis because best outcomes are seen with early initiation of appropriate therapies. Here we sought to improve the diagnostic odyssey by… read more here.
Keywords: diagnosis; disease subtype; subtype specific; glycosaminoglycan fragments ... See more keywords
Subtype-specific regulatory network rewiring in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2018 at "Nature genetics"
DOI: 10.1038/s41588-018-0270-1
Abstract: Acute myeloid leukemia (AML) is a heterogeneous disease caused by a variety of alterations in transcription factors, epigenetic regulators and signaling molecules. To determine how different mutant regulators establish AML subtype–specific transcriptional networks, we performed… read more here.
Keywords: network; subtype specific; myeloid leukemia; acute myeloid ... See more keywords
An enzyme-powered microRNA discriminator for the subtype-specific diagnosis of breast cancer
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Science"
DOI: 10.1039/d3sc00090g
Abstract: Breast cancer, a disease with highly heterogeneous features, is the most common malignancy diagnosed in people worldwide. Early diagnosis of breast cancer is crucial for improving its cure rate, and accurate classification of the subtype-specific… read more here.
Keywords: breast cancer; breast; subtype specific; discriminator ... See more keywords