Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-05892-0
Abstract: The heterogeneity of neurodegenerative diseases is a key confound to disease understanding and treatment development, as study cohorts typically include multiple phenotypes on distinct disease trajectories. Here we introduce a machine-learning technique—Subtype and Stage Inference… read more here.
Keywords: sustain; heterogeneity; neurodegenerative diseases; disease ... See more keywords
Spatial-Temporal Patterns of β-Amyloid Accumulation: A Subtype and Stage Inference Model Analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Neurology"
DOI: 10.1212/wnl.0000000000201144
Abstract: Background and Objectives β -amyloid (A β ) staging models assume a single spatial-temporal progression of amyloid accumulation. We assessed evidence for A β accumulation subtypes by applying the data-driven Subtype and Stage Inference (SuStaIn)… read more here.
Keywords: amyloid accumulation; accumulation; subtype stage; spatial temporal ... See more keywords