Subunit Exchange and Activation of Human CaMKII Variants
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.207
Abstract: Ca2+-calmodulin dependent protein kinase II (CaMKII) assembles into an oligomeric ring in which the kinase domains are organized around a central hub. Notably, the stimulated activity of CaMKII persists even after the withdrawal of a… read more here.
Keywords: human camkii; camkii; linker; activation ... See more keywords
Oxidation of Dueling Cysteine Promotes Subunit Exchange in SOD1.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.3c00174
Abstract: The heterodimerization of wild-type (WT) Cu, Zn superoxide dismutase-1 (SOD1) and mutant SOD1 might be a critical step in the pathogenesis of SOD1-linked amyotrophic lateral sclerosis (ALS). Post-translational modifications that accelerate SOD1 heterodimerization remain unidentified.… read more here.
Keywords: oxidation; heterodimerization; sod1; promotes subunit ... See more keywords