P2X2 receptor subunit interfaces are missense variant hotspots, where mutations tend to increase apparent ATP affinity
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1101/2021.03.26.436616
Abstract: Background and Purpose P2X receptors (P2XRs) are trimeric ligand-gated ion channels (LGICs) that open a cation-selective pore in response to ATP binding to their large extracellular domain (ECD). The seven known P2XR subtypes can assemble… read more here.
Keywords: subunit interfaces; p2x2 receptor; apparent atp; atp affinity ... See more keywords
Functional sites for anesthetics in GABAA receptors
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DOI: 10.18632/oncotarget.14616
Abstract: A key target for the intravenous anesthetics propofol and etomidate is the γ-aminobutyric acid type A (GABAA) receptor [1]. GABAA receptors are the most important inhibitory neurotransmitter receptors in the central nervous system. They are… read more here.
Keywords: subunit interfaces; gabaa receptors; anesthetics gabaa; potentiation ... See more keywords