TOP-2 is differentially required for the proper maintenance of the cohesin subunit REC-8 on meiotic chromosomes in C. elegans spermatogenesis and oogenesis.
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DOI: 10.1093/genetics/iyac120
Abstract: During meiotic prophase I, accurate segregation of homologous chromosomes requires the establishment of chromosomes with a meiosis-specific architecture. The sister chromatid cohesin complex and the enzyme Topoisomerase II are important components of meiotic chromosome architecture,… read more here.
Keywords: cohesin subunit; spermatogenesis oogenesis; subunit rec; chromosome ... See more keywords