Hemagglutinin Functionalized Liposomal Vaccines Enhance Germinal Center and Follicular Helper T Cell Immunity
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202002142
Abstract: Abstract Despite remarkable successes of immunization in protecting public health, safe and effective vaccines against a number of life‐threatening pathogens such as HIV, ebola, influenza, and SARS‐CoV‐2 remain urgently needed. Subunit vaccines can avoid potential… read more here.
Keywords: cell; follicular helper; liposomal vaccines; helper cell ... See more keywords
Discovery of T-cell Driven Subunit Vaccines from Zika Virus Genome: An Immunoinformatics Approach
Sign Up to like & getrecommendations! Published in 2017 at "Interdisciplinary Sciences, Computational Life Sciences"
DOI: 10.1007/s12539-017-0238-3
Abstract: The recent outbreaks of Zika virus and the absence of a specific therapy have necessitated to identify T-cell-stimulating antigenic peptides as potential subunit vaccine candidates. The translated ssRNA (+) genome of Zika virus was explored… read more here.
Keywords: cell epitopes; vaccines zika; zika virus; cell ... See more keywords
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses
Sign Up to like & getrecommendations! Published in 2021 at "Immunity"
DOI: 10.1016/j.immuni.2021.11.001
Abstract: Adjuvants are critical for improving the quality and magnitude of adaptive immune responses to vaccination. Lipid nanoparticle (LNP)-encapsulated nucleoside-modified mRNA vaccines have shown great efficacy against SARS-CoV-2, but the mechanism of action of this vaccine… read more here.
Keywords: mrna protein; protein subunit; helper cell; follicular helper ... See more keywords
Re-burying Artificially Exposed Surface of Viral Subunit Vaccines Through Oligomerization Enhances Vaccine Efficacy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.927674
Abstract: Viral subunit vaccines often suffer low efficacy. We recently showed that when taken out of the context of whole virus particles, recombinant subunit vaccines contain artificially exposed surface regions that are non-neutralizing and reduce their… read more here.
Keywords: artificially exposed; subunit vaccines; exposed surface; efficacy ... See more keywords
Immunoinformatic-based design of immune-boosting multiepitope subunit vaccines against monkeypox virus and validation through molecular dynamics and immune simulation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1042997
Abstract: Monkeypox virus is the causative agent of monkeypox disease, belonging to an orthopoxvirus genus, with a disease pattern similar to that of smallpox. The number of monkeypox cases have robustly increased recently in several countries… read more here.
Keywords: monkeypox virus; subunit vaccines; multiepitope subunit; simulation ... See more keywords
Subunit vaccines for Acinetobacter baumannii
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1088130
Abstract: Acinetobacter baumannii is a gram-negative bacterium and a crucial opportunistic pathogen in hospitals. A. baumannii infection has become a challenging problem in clinical practice due to the increasing number of multidrug-resistant strains and their prevalence… read more here.
Keywords: vaccines acinetobacter; subunit vaccines; baumannii subunit; acinetobacter baumannii ... See more keywords
A platform technology for generating subunit vaccines against diverse viral pathogens
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.963023
Abstract: The COVID-19 pandemic response has shown how vaccine platform technologies can be used to rapidly and effectively counteract a novel emerging infectious disease. The speed of development for mRNA and vector-based vaccines outpaced those of… read more here.
Keywords: platform technology; clamp; subunit vaccines; mers cov ... See more keywords
A Comprehensive Review of the Protein Subunit Vaccines Against COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.927306
Abstract: Two years after severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), in December 2019, the first infections were identified in Wuhan city of China. SARS-CoV-2 infection caused a global pandemic and accordingly, 5.41 million deaths worldwide. Hence,… read more here.
Keywords: subunit vaccines; protein subunit; vaccine; review protein ... See more keywords
The Versatile Manipulations of Self-Assembled Proteins in Vaccine Design
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22041934
Abstract: Protein assemblies provide unique structural features which make them useful as carrier molecules in biomedical and chemical science. Protein assemblies can accommodate a variety of organic, inorganic and biological molecules such as small proteins and… read more here.
Keywords: protein; protein assemblies; versatile manipulations; structural features ... See more keywords
Effect of Different Adjuvants on Immune Responses Elicited by Protein-Based Subunit Vaccines against SARS-CoV-2 and Its Delta Variant
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14030501
Abstract: The global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become more serious because of the continuous emergence of variants of concern (VOC), thus calling for the… read more here.
Keywords: based subunit; subunit vaccines; delta variant; sars cov ... See more keywords
Adjuvants and Antigen-Delivery Systems for Subunit Vaccines against Tuberculosis
Sign Up to like & getrecommendations! Published in 2021 at "Vaccines"
DOI: 10.3390/vaccines9090972
Abstract: The only licensed vaccine against tuberculosis is BCG. However, BCG has failed to provide consistent protection against tuberculosis, especially pulmonary disease in adults. Furthermore, the use of BCG is contraindicated in immunocompromised subjects. The research… read more here.
Keywords: delivery systems; tuberculosis; adjuvants antigen; subunit vaccines ... See more keywords