Mirogabalin activates the descending noradrenergic system by binding to the α2δ-1 subunit of voltage-gated Ca2+ channels to generate analgesic effects.
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DOI: 10.1016/j.jphs.2021.01.002
Abstract: Gabapentinoids such as gabapentin and pregabalin, which bind specifically to the α2δ subunit of voltage-gated Ca2+ channels, are used for first-line treatment of neuropathic pain. Here, we examined the analgesic effect of mirogabalin besilate (referred… read more here.
Keywords: system; descending noradrenergic; gated ca2; analgesic effects ... See more keywords