Total Synthesis of the Acetyl CoA Carboxylase Inhibitor Soraphen A: Asymmetric Tsuji Reduction Enables Successive Olefin Metathesis.
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DOI: 10.1021/jacs.1c12063
Abstract: The total synthesis of soraphen A, a myxobacterial metabolite and inhibitor of acetyl CoA carboxylase, was completed in 11 steps (longest linear sequence), less than half the steps previously required. Seven metal-catalyzed processes were deployed… read more here.
Keywords: coa carboxylase; acetyl coa; tsuji reduction; total synthesis ... See more keywords