Succinate Dehydrogenase Subunit A (SDHA) Mediated Microglia Extracellular Traps Formation Participating in Cerebral Ischemic Reperfusion Injury
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202411873
Abstract: Ischemia reperfusion (I/R) injury associated with recanalization therapy in acute ischemic stroke (AIS) exacerbates the initial brain damage. However, it remains a clinical challenge due to limited understanding of the underlying mechanisms of I/R injury.… read more here.
Keywords: succinate dehydrogenase; reperfusion injury; injury; extracellular traps ... See more keywords
Metabolic Effects of Succinate Dehydrogenase Loss in Cancer
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DOI: 10.1002/jcp.70066
Abstract: Succinate dehydrogenase (SDH) is both Complex II in the electron transport chain (ETC) and a key metabolic enzyme in the tricarboxylic acid cycle. SDH is a heterotetrameric enzyme consisting of four subunits SDHA, SDHB, SDHC,… read more here.
Keywords: succinate dehydrogenase; loss; sdh loss; physiology ... See more keywords
Fusarium graminearum FgSdhC1 point mutation A78V confers resistance to the succinate dehydrogenase inhibitor pydiflumetofen.
Sign Up to like & getrecommendations! Published in 2022 at "Pest management science"
DOI: 10.1002/ps.6795
Abstract: BACKGROUND Fusarium head blight (FHB) caused by Fusarium graminearum complex (Fg) is a devastating disease of cereal crops worldwide. The succinate dehydrogenase inhibitor (SDHI), pydiflumetofen, has been registered for management of FHB in China in… read more here.
Keywords: point mutation; pydiflumetofen; resistance; fusarium graminearum ... See more keywords
Binding differences of fluxapyroxad with succinate dehydrogenase across species: insights from in silico simulations
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DOI: 10.1002/ps.70191
Abstract: Elucidating the species selectivity mechanism of succinate dehydrogenase (SDH) inhibitors (SDHIs) is crucial for the discovery novel eco‐friendly SDHI fungicides. Fluxapyroxad (FLX), a representative SDHI, was investigated through in silico study to identify species‐specific differences… read more here.
Keywords: succinate dehydrogenase; fluxapyroxad succinate; differences fluxapyroxad; dehydrogenase across ... See more keywords
Novel quinolin-2(1H)-one analogous as potential fungicides targeting succinate dehydrogenase: design, synthesis, inhibitory evaluation and molecular modeling.
Sign Up to like & getrecommendations! Published in 2022 at "Pest management science"
DOI: 10.1002/ps.7332
Abstract: BACKGROUND Succinate dehydrogenase is an important target of fungicides. Succinate dehydrogenase inhibitors have widely been used to combat destructive plant pathogenic fungi because they possess efficient and broad-spectrum antifungal activities and as well as unique… read more here.
Keywords: antifungal activities; one analogous; quinolin one; novel quinolin ... See more keywords
Design, synthesis, and antifungal activity of novel dithiin tetracarboximide derivatives as potential succinate dehydrogenase inhibitors.
Sign Up to like & getrecommendations! Published in 2023 at "Pest management science"
DOI: 10.1002/ps.7369
Abstract: BACKGROUND Succinate dehydrogenase inhibitor (SDHI) fungicides are an important class of agricultural fungicides with the advantages of high efficiency and a broad bactericidal spectrum. In order to pursue novel SDHIs, a series of N-substituted dithiin… read more here.
Keywords: antifungal activity; dithiin tetracarboximide; tetracarboximide derivatives; activity ... See more keywords
Current management of succinate dehydrogenase–deficient gastrointestinal stromal tumors
Sign Up to like & getrecommendations! Published in 2019 at "Cancer and Metastasis Reviews"
DOI: 10.1007/s10555-019-09818-0
Abstract: Gastrointestinal stromal tumors (GISTs) are increasingly recognized as having diverse biology. With the development of tyrosine kinase inhibitors molecularly matched to oncogenic KIT and PDGFRA mutations, GISTs have become a quintessential model for precision oncology.… read more here.
Keywords: sdh deficient; gastrointestinal stromal; stromal tumors; biology ... See more keywords
Sensitivity of Fusarium asiaticum to a novel succinate dehydrogenase inhibitor fungicide pydiflumetofen
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DOI: 10.1016/j.cropro.2017.02.011
Abstract: Abstract Fusarium head blight (FHB) or scab mainly caused by Fusarium asiaticum is a devastating fungal disease in wheat. In China, carbendazim (MBC) and its co-formulated mixture with other fungicides are the main fungicides for… read more here.
Keywords: novel succinate; fungicide pydiflumetofen; fusarium asiaticum; dehydrogenase inhibitor ... See more keywords
A variant of uncertain significance in SDHAF1, the succinate dehydrogenase chaperone protein, in an adult patient with spastic paraparesis and leukoencephalopathy.
Sign Up to like & getrecommendations! Published in 2021 at "Multiple sclerosis and related disorders"
DOI: 10.1016/j.msard.2021.103132
Abstract: Succinate dehydrogenase (SDH), or respiratory complex II, consists of four nuclear-encoded subunits. The chaperone protein succinate dehydrogenase assembly factor 1 (SDHAF1) plays an essential role in the assembly of SDH, and in the incorporation of… read more here.
Keywords: chaperone protein; uncertain significance; variant uncertain; sdhaf1 ... See more keywords
Design, Synthesis and Evaluation of Antifungal Activity of Novel Pyrazole-thiazole Carboxamides as Succinate Dehydrogenase Inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.0c00062
Abstract: Succinate dehydrogenase (SDH) is regarded as a promising target for fungicide discovery. To continue our ongoing studies on the discovery of novel SDH inhibitors as fungicides, novel pyrazole-thiazole carboxamides were designed, synthesized, and evaluated for… read more here.
Keywords: pyrazole thiazole; thiazole carboxamides; novel pyrazole; antifungal activity ... See more keywords
Synthesis, Biological Evaluation, and 3D-QSAR Studies of N-(Substituted pyridine-4-yl)-1-(substituted phenyl)-5-trifluoromethyl-1H-pyrazole-4-carboxamide Derivatives as Potential Succinate Dehydrogenase Inhibitors.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.0c05702
Abstract: A series of new fungicides that can inhibit the succinate dehydrogenase (SDH) was classified and named as SDH inhibitors by the Fungicide Resistance Action Committee in 2009. To develop more potential SDH inhibitors, we designed… read more here.
Keywords: carboxamide derivatives; pyrazole carboxamide; trifluoromethyl pyrazole; substituted pyridine ... See more keywords