Structure-Activity Investigations and Optimisations of Non-metabolite Agonists for the Succinate Receptor 1
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-28263-7
Abstract: The succinate receptor 1 (SUCNR1) is a receptor for the metabolite succinate, which functions as a metabolic stress signal in the liver, kidney, adipose tissue and the retina. However, potent non-metabolite tool compounds are needed… read more here.
Keywords: receptor; succinate receptor; non metabolite; structure activity ... See more keywords
Identification and pharmacological characterization of succinate receptor agonists
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Pharmacology"
DOI: 10.1111/bph.13738
Abstract: The succinate receptor (formerly GPR91 or SUCNR1) is described as a metabolic sensor that may be involved in homeostasis. Notwithstanding its implication in important (patho)physiological processes, the function of succinate receptors has remained ill‐defined because… read more here.
Keywords: pharmacological characterization; succinate receptor; identification pharmacological; succinate ... See more keywords
Increased succinate receptor GPR91 involved in the pathogenesis of Mooren's ulcer.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of ophthalmology"
DOI: 10.18240/ijo.2018.11.01
Abstract: AIM To investigate the expression of succinate receptor GPR91 and its pathogenic roles in Mooren's ulcer (MU). METHODS Biopsy specimens were obtained from 7 patients with MU and 6 healthy donors. The expression of GPR91… read more here.
Keywords: receptor gpr91; gpr91; succinate receptor; mmp ... See more keywords