Characterization and quantification of succinimide using peptide mapping under low-pH conditions and hydrophobic interaction chromatography.
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DOI: 10.1016/j.ab.2018.11.021
Abstract: Characterization of asparagine deamidation and aspartic acid isomerization is an important aspect of biotherapeutic protein analysis due to the potential negative effect of these modifications on drug efficacy and stability. Succinimide has long been known… read more here.
Keywords: hydrophobic interaction; mapping low; interaction chromatography; peptide mapping ... See more keywords