Fumarate Hydratase and S-(2-Succinyl)-Cysteine Immunohistochemistry Shows Evidence of Fumarate Hydratase Deficiency in 2% of Uterine Leiomyosarcomas: A Cohort Study of 348 Tumors
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DOI: 10.1097/pgp.0000000000000918
Abstract: Approximately 1% to 1.5% of uterine leiomyomas are fumarate hydratase (FH)-deficient (FHd). A subset of these are associated with germline FH mutations. However, the prevalence and clinicopathologic characteristics of FHd uterine leiomyosarcoma (uLMS) remain unknown.… read more here.
Keywords: hydratase; immunohistochemistry; succinyl cysteine; fumarate hydratase ... See more keywords
Mitochondrial stress and glycoxidation increase with decreased kidney function
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Clinical Biochemistry and Nutrition"
DOI: 10.3164/jcbn.22-101
Abstract: Mitochondrial stress increases the production of fumarate, an intermediate of the Krebs cycle. Fumarate non-enzymatically reacts with the thiol group of cysteine, leading to the production of S-(2-succinyl)cysteine. Here, we quantified the concentration of fumarate,… read more here.
Keywords: succinyl cysteine; disease; kidney; kidney function ... See more keywords