Succinylation Inhibits the Enzymatic Hydrolysis of the Extracellular Matrix Protein Fibrillin 1 and Promotes Gastric Cancer Progression
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202200546
Abstract: Extracellular matrix (ECM) remodeling is crucial in the regulation of gastric cancer (GC) progression. This work aims to reveal novel posttranslational modifications and their relevant mechanisms in GC. In 3D matrix culture and animal models,… read more here.
Keywords: extracellular matrix; fbn1; succinylation; progression ... See more keywords
Relationship between flexibility and interfacial functional properties of soy protein isolate: Succinylation modification.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.12012
Abstract: BACKGROUND In this paper, the effects of different succinic anhydride (SA) additions on the flexibility of soy protein isolate (SPI) were investigated, and changes in protein conformation and interfacial functional properties were measured. The structure-effect… read more here.
Keywords: interfacial functional; protein isolate; succinylation; flexibility ... See more keywords
Global profiling of lysine succinylation in human lungs
Sign Up to like & getrecommendations! Published in 2022 at "PROTEOMICS"
DOI: 10.1002/pmic.202100381
Abstract: The lysine succinylation (Ksucc) is involved in many core energy metabolism pathways and affects the metabolic process in mitochondria, making this modification highly valuable for studying diseases related to mitochondrial disorders. In this paper, we… read more here.
Keywords: human lungs; succinylation human; succinylation; global profiling ... See more keywords
Succinylation Links Metabolism to Protein Functions
Sign Up to like & getrecommendations! Published in 2019 at "Neurochemical Research"
DOI: 10.1007/s11064-019-02780-x
Abstract: Post-translational modifications (PTMs) are important regulators of protein function, and integrate metabolism with physiological and pathological processes. Phosphorylation and acetylation are particularly well studied PTMs. A relatively recently discovered novel PTM is succinylation in which… read more here.
Keywords: metabolism protein; succinylation; metabolism; succinylation links ... See more keywords
Effect of succinylation on the secondary structures, surface, and thermal properties of date palm pollen protein concentrate
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Food Science and Technology"
DOI: 10.1007/s13197-020-04577-1
Abstract: The present study was attempted to investigate the effect of succinylation, as chemical modification, on the functionality of male date palm pollen protein concentrate (MDPPPC). Succinylation was applied at two levels, 4 and 8 mol of… read more here.
Keywords: protein; effect succinylation; succinylation; date palm ... See more keywords
Global analysis of protein succinylation modification of Nostoc flagelliforme in response to dehydration.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2021.104149
Abstract: Nostoc flagelliforme is a type of terrestrial cyanobacteria that is distributed in arid or semi-arid steppes in China. To research the molecular mechanisms underlying the adaptation of N. flagelliforme to drought stress, the succinylated expression… read more here.
Keywords: nostoc flagelliforme; succinylation; succinylated proteins; response dehydration ... See more keywords
PSSM-Suc: Accurately predicting succinylation using position specific scoring matrix into bigram for feature extraction.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2017.05.005
Abstract: Post-translational modification (PTM) is a covalent and enzymatic modification of proteins, which contributes to diversify the proteome. Despite many reported PTMs with essential roles in cellular functioning, lysine succinylation has emerged as a subject of… read more here.
Keywords: specific scoring; pssm suc; succinylation; pssm ... See more keywords
Defining decreased protein succinylation of failing human cardiac myofibrils in ischemic cardiomyopathy.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2019.11.159
Abstract: Succinylation is a post-translational modification of protein lysine residues with succinyl groups derived from succinyl CoA. Succinylation is considered a significant post-translational modification with the potential to impact protein function which is highly conserved across… read more here.
Keywords: heart; ischemic cardiomyopathy; succinylation; heart failure ... See more keywords
The global succinylation of SARS-CoV-2–infected host cells reveals drug targets
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2123065119
Abstract: Significance The continued rapid evolution of SARS-CoV-2 and the emergence of immune-evading variants pose significant challenges to COVID-19 prevention and control, highlighting the urgent need for development of novel antiviral therapies. Our study found that… read more here.
Keywords: succinylation; global succinylation; cov infected; host ... See more keywords
Physicochemical and emulsifying properties of mung bean protein isolate as influenced by succinylation
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Food Properties"
DOI: 10.1080/10942912.2018.1502200
Abstract: ABSTRACT The application of mung bean protein in foods is limited due to its poor functionality. Acylation with succinic anhydride could be used to improve the functionalities of protein. In this study, the influence of… read more here.
Keywords: protein; bean protein; anhydride protein; succinylation ... See more keywords
Semisynthesis of site-specifically succinylated histone reveals that succinylation regulates nucleosome unwrapping rate and DNA accessibility
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa663
Abstract: Abstract Posttranslational modifications (PTMs) of histones represent a crucial regulatory mechanism of nucleosome and chromatin dynamics in various of DNA-based cellular processes, such as replication, transcription and DNA damage repair. Lysine succinylation (Ksucc) is a… read more here.
Keywords: succinylation; dna; site specifically; semisynthesis site ... See more keywords