Succinylation Inhibits the Enzymatic Hydrolysis of the Extracellular Matrix Protein Fibrillin 1 and Promotes Gastric Cancer Progression
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202200546
Abstract: Extracellular matrix (ECM) remodeling is crucial in the regulation of gastric cancer (GC) progression. This work aims to reveal novel posttranslational modifications and their relevant mechanisms in GC. In 3D matrix culture and animal models,… read more here.
Keywords: extracellular matrix; fbn1; succinylation; progression ... See more keywords
KAT3B Promotes the Glycolysis and Malignant Progression of Lung Cancer by Mediating the Succinylation Modification of PKM2
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70259
Abstract: Lysine succinyltransferase KAT3B plays a critical role in the progression of various cancers by modulating key metabolic pathways, including glycolysis. However, the function and underlying mechanism of KAT3B in glycolysis and lung cancer (LC) progression… read more here.
Keywords: succinylation; pkm2; lung cancer; progression ... See more keywords
Relationship between flexibility and interfacial functional properties of soy protein isolate: Succinylation modification.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.12012
Abstract: BACKGROUND In this paper, the effects of different succinic anhydride (SA) additions on the flexibility of soy protein isolate (SPI) were investigated, and changes in protein conformation and interfacial functional properties were measured. The structure-effect… read more here.
Keywords: interfacial functional; protein isolate; succinylation; flexibility ... See more keywords
Global profiling of lysine succinylation in human lungs
Sign Up to like & getrecommendations! Published in 2022 at "PROTEOMICS"
DOI: 10.1002/pmic.202100381
Abstract: The lysine succinylation (Ksucc) is involved in many core energy metabolism pathways and affects the metabolic process in mitochondria, making this modification highly valuable for studying diseases related to mitochondrial disorders. In this paper, we… read more here.
Keywords: human lungs; succinylation human; succinylation; global profiling ... See more keywords
Succinylation Links Metabolism to Protein Functions
Sign Up to like & getrecommendations! Published in 2019 at "Neurochemical Research"
DOI: 10.1007/s11064-019-02780-x
Abstract: Post-translational modifications (PTMs) are important regulators of protein function, and integrate metabolism with physiological and pathological processes. Phosphorylation and acetylation are particularly well studied PTMs. A relatively recently discovered novel PTM is succinylation in which… read more here.
Keywords: metabolism protein; succinylation; metabolism; succinylation links ... See more keywords
Effect of succinylation on the secondary structures, surface, and thermal properties of date palm pollen protein concentrate
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Food Science and Technology"
DOI: 10.1007/s13197-020-04577-1
Abstract: The present study was attempted to investigate the effect of succinylation, as chemical modification, on the functionality of male date palm pollen protein concentrate (MDPPPC). Succinylation was applied at two levels, 4 and 8 mol of… read more here.
Keywords: protein; effect succinylation; succinylation; date palm ... See more keywords
Global analysis of protein succinylation modification of Nostoc flagelliforme in response to dehydration.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2021.104149
Abstract: Nostoc flagelliforme is a type of terrestrial cyanobacteria that is distributed in arid or semi-arid steppes in China. To research the molecular mechanisms underlying the adaptation of N. flagelliforme to drought stress, the succinylated expression… read more here.
Keywords: nostoc flagelliforme; succinylation; succinylated proteins; response dehydration ... See more keywords
PSSM-Suc: Accurately predicting succinylation using position specific scoring matrix into bigram for feature extraction.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2017.05.005
Abstract: Post-translational modification (PTM) is a covalent and enzymatic modification of proteins, which contributes to diversify the proteome. Despite many reported PTMs with essential roles in cellular functioning, lysine succinylation has emerged as a subject of… read more here.
Keywords: specific scoring; pssm suc; succinylation; pssm ... See more keywords
Defining decreased protein succinylation of failing human cardiac myofibrils in ischemic cardiomyopathy.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2019.11.159
Abstract: Succinylation is a post-translational modification of protein lysine residues with succinyl groups derived from succinyl CoA. Succinylation is considered a significant post-translational modification with the potential to impact protein function which is highly conserved across… read more here.
Keywords: heart; ischemic cardiomyopathy; succinylation; heart failure ... See more keywords
Succinylation of GyrB Is a Mechanism Conferring Fluoroquinolone Resistance.
Sign Up to like & getrecommendations! Published in 2025 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.5c00781
Abstract: Being a persistent and deadly infection, tuberculosis (TB) caused by Mycobacterium tuberculosis remains a global health challenge. Despite having a well-established 4-drug combination therapy for drug-sensitive TB, the emergence of drug-resistant TB has rendered the… read more here.
Keywords: resistance; succinylation; dna gyrase; tuberculosis ... See more keywords
KAT2A-driven succinylation of SRSF11 enforces spliceosome-mediated RAD52 splicing to promote homologous recombination and radioresistance in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2025 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-025-02458-7
Abstract: Posttranslational modification succinylation plays a pivotal role in tumorigenesis across malignancies, yet its mechanistic contributions to hepatocellular carcinoma (HCC) pathogenesis and therapeutic resistance remain poorly characterized. In this study, we systematically demonstrated that the splicing… read more here.
Keywords: rad52; srsf11; succinylation; hcc ... See more keywords