Succinate receptor 1 inhibits mitochondrial respiration in cancer cells addicted to glutamine.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.11.024
Abstract: Cancer cells display metabolic alterations to meet the bioenergetic demands for their high proliferation rates. Succinate is a central metabolite of the tricarboxylic acid (TCA) cycle, but was also shown to act as an oncometabolite… read more here.
Keywords: mitochondrial respiration; sucnr1; cancer cells; cancer ... See more keywords
P043 Succinate receptor (SUCNR1) mediates leukocyte-endothelial cell interactions induced by TNFa
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjab076.172
Abstract: The Krebs cycle metabolite succinate contributes to inflammatory conditions like arthritis and colitis by activating its receptor SUCNR1. We aimed to analyze whether the succinate-SUCNR1 pathway contributes to the leukocyte-endothelial cell interactions that initiate the… read more here.
Keywords: sucnr1; endothelial cell; succinate; cell interactions ... See more keywords
HDAC8 Promotes Liver Metastasis of Colorectal Cancer via Inhibition of IRF1 and Upregulation of SUCNR1
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/2815187
Abstract: Histone deacetylases (HDACs) are well-characterized for their involvement in tumor progression. Herein, the current study set out to unravel the association of HDAC8 with colorectal cancer (CRC). Bioinformatics analyses were carried out to retrieve the… read more here.
Keywords: hdac8; cell; sucnr1; crc ... See more keywords
SUCNR1 Mediates the Priming Step of the Inflammasome in Intestinal Epithelial Cells: Relevance in Ulcerative Colitis
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10030532
Abstract: Intestinal epithelial cells (IECs) constitute a defensive physical barrier in mucosal tissues and their disruption is involved in the etiopathogenesis of several inflammatory pathologies, such as Ulcerative Colitis (UC). Recently, the succinate receptor SUCNR1 was… read more here.
Keywords: sucnr1; ulcerative colitis; epithelial cells; receptor ... See more keywords
Divulging a Pleiotropic Role of Succinate Receptor SUCNR1 in Renal Cell Carcinoma Microenvironment
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14246064
Abstract: Simple Summary Renal cell carcinoma (RCC) is one of the most life-threatening urological neoplasms. The tumor microenvironment comprising immune cell infiltration is a key factor for treatment response and survival of RCC patients. In addition,… read more here.
Keywords: cell; microenvironment; renal cell; rcc ... See more keywords