Meloxicam methyl group determines enzyme specificity for thiazole bioactivation compared to sudoxicam.
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DOI: 10.1016/j.toxlet.2020.11.015
Abstract: Meloxicam is a thiazole-containing NSAID that was approved for marketing with favorable clinical outcomes despite being structurally similar to the hepatotoxic sudoxicam. Introduction of a single methyl group on the thiazole results in an overall… read more here.
Keywords: sudoxicam; methyl group; group; bioactivation ... See more keywords