Selective Synthesis of Unsymmetrical Disulfides from Thiols via Water-Removable SuFEx Reagent.
Sign Up to like & getrecommendations! Published in 2025 at "Organic letters"
DOI: 10.1021/acs.orglett.5c02260
Abstract: A SuFEx reagent was designed for chemoselective synthesis of unsymmetrical disulfide, featuring a triethoxysilane moiety and a sulfonyl fluoride group activated by a γ-sulfur atom. It reacts with a more acidic thiol to form a… read more here.
Keywords: selective synthesis; unsymmetrical disulfides; sufex reagent; reagent ... See more keywords
Strain-release driven reactivity of a chiral SuFEx reagent provides stereocontrolled access to sulfinamides, sulfonimidamides, and sulfoximines
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-51224-w
Abstract: Efforts aimed at enriching the chemical and structural diversity of small molecules have invigorated synthetic exploration in the last two decades. Spatially defined molecular functionality serves as the foundation to construct unique chemical space to… read more here.
Keywords: strain release; chiral sufex; chemical space; sufex reagent ... See more keywords