Structural modifications in the sugar moiety as a key to improving the anticancer effectiveness of doxorubicin.
Sign Up to like & getrecommendations! Published in 2017 at "Life sciences"
DOI: 10.1016/j.lfs.2017.04.009
Abstract: Doxorubicin (DOX) is one of the most commonly used and effective chemotherapeutic agents. Despite its clinical benefits, the use of DOX is often limited by serious adverse effects, such as severe cardiotoxicity and myelosuppression. Recent… read more here.
Keywords: structural modifications; modifications sugar; moiety; anticancer ... See more keywords
Conformation-dependent restraints for polynucleotides: the sugar moiety
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz1122
Abstract: Abstract Stereochemical restraints are commonly used to aid the refinement of macromolecular structures obtained by experimental methods at lower resolution. The standard restraint library for nucleic acids has not been updated for over two decades… read more here.
Keywords: geometry; sugar moiety; conformation dependent;