Significant impact of divalent metal ions on the fidelity, sugar selectivity, and drug incorporation efficiency of human PrimPol.
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DOI: 10.1016/j.dnarep.2016.11.003
Abstract: Human PrimPol is a recently discovered bifunctional enzyme that displays DNA template-directed primase and polymerase activities. PrimPol has been implicated in nuclear and mitochondrial DNA replication fork progression and restart as well as DNA lesion… read more here.
Keywords: mn2; primpol; human primpol; sugar selectivity ... See more keywords