MicroRNA‐based recombinant AAV vector assembly improves efficiency of suicide gene transfer in a murine model of lymphoma
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.2935
Abstract: Recent success in clinical trials with recombinant Adeno‐associated virus (AAV)‐based gene therapy has redirected efforts in optimizing AAV assembly and production, to improve its potency. We reasoned that inclusion of a small RNA during vector… read more here.
Keywords: vector; suicide gene; vector assembly; gene transfer ... See more keywords
Suicide Gene Therapy of Oral Squamous Cell Carcinoma and Cervical Carcinoma In Vitro.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8922-5_14
Abstract: Suicide gene therapy induced by the Herpes Simplex Virus thymidine kinase/ganciclovir (HSV-tk/GCV) system has been utilized to successfully treat various cancers. We describe TransfeX-mediated transfection of pCMV.Luc into HeLa cervical carcinoma and HSC-3, FaDu, and… read more here.
Keywords: suicide gene; carcinoma; oral squamous; gene therapy ... See more keywords
Glycopolymers Mediate Suicide Gene Therapy in ASGPR-Expressing Hepatocellular Carcinoma Cells in Tandem with Docetaxel
Sign Up to like & getrecommendations! Published in 2023 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c01329
Abstract: Cationic glycopolymers stand out as gene delivery nanosystems due to their inherent biocompatibility and high binding affinity to the asialoglycoprotein receptor (ASGPR), a target receptor overexpressed in hepatocellular carcinoma (HCC) cells. However, their synthesis procedure… read more here.
Keywords: suicide gene; hepatocellular carcinoma; gene; gene therapy ... See more keywords
Development of an Optimized Promoter System for Exosomal and Naked AAV Vector-Based Suicide Gene Therapy in Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2024 at "ACS Omega"
DOI: 10.1021/acsomega.4c03949
Abstract: Suicide gene therapy is a promising strategy for the potential treatment of hepatocellular carcinoma (HCC). However, the lack of high transduction efficiency and targeted vectors in delivering the suicide genes to only the HCC cells… read more here.
Keywords: promoter; hepatocellular carcinoma; gene therapy; gene ... See more keywords
FGFR4-specific CAR-T cells with inducible caspase-9 suicide gene as an approach to treat rhabdomyosarcoma
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Gene Therapy"
DOI: 10.1038/s41417-024-00823-2
Abstract: Metastatic rhabdomyosarcoma is associated with poor survival and unsatisfactory treatment outcomes. Therefore, new immunotherapeutic methods are urgently required. Fibroblast growth factor receptor 4 (FGFR4), a new therapeutic target for rhabdomyosarcoma, plays a crucial role in… read more here.
Keywords: rhabdomyosarcoma; car; fgfr4; car cells ... See more keywords
Arf6-mediated macropinocytosis-enhanced suicide gene therapy of C16TAB-condensed Tat/pDNA nanoparticles in ovarian cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Nanoscale"
DOI: 10.1039/d1nr03974a
Abstract: The use of cell-penetrating peptides (CPPs), typically HIV-Tat, to deliver therapeutic genes for cancer treatment is hampered by the inefficient delivery and complicated uptake route of plasmid DNA (pDNA). On the one hand, surface charges,… read more here.
Keywords: suicide gene; gene therapy; tat pdna; cancer ... See more keywords
CNSC-22. TARGETING SOX9-POSITIVE THERAPY-RESISTANT MEDULLOBLASTOMA WITH A NOVEL SUICIDE GENE THERAPY
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf201.0230
Abstract: The transcription factor SOX9 is a marker of poor prognosis and therapy resistance in medulloblastoma, one of the most common malignant brain tumor types in children. Knockdown or downregulation of SOX9 inhibits medulloblastoma recurrence in… read more here.
Keywords: therapy; sox9 positive; gene therapy; suicide gene ... See more keywords
EXTH-86. Therapeutic Potential of SHED-Derived Suicide Gene Therapy for Brain Tumors Using HSV-TK/Ganciclovir System
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf201.1419
Abstract: Effective treatment of malignant brain tumors remains a significant challenge due to their infiltrative nature and resistance to conventional therapies. Suicide gene therapy using herpes simplex virus thymidine kinase (HSV-TK) in combination with ganciclovir (GCV)… read more here.
Keywords: brain; brain tumors; hsv; tumor ... See more keywords
Long-term treatment with valganciclovir improves lentiviral suicide gene therapy of glioblastoma.
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-oncology"
DOI: 10.1093/neuonc/noz060
Abstract: BACKGROUND Suicide gene therapy for malignant gliomas has shown encouraging results in the latest clinical trials. However, prodrug application was most often restricted to short-term treatment (14 days), especially when replication-defective vectors were used. We… read more here.
Keywords: term; treatment; gene therapy; term treatment ... See more keywords
Combinatorial suicide gene strategies for the safety of cell therapies
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.975233
Abstract: Gene-modified cellular therapies carry inherent risks of severe and potentially fatal adverse events, including the expansion of alloreactive cells or malignant transformation due to insertional mutagenesis. Strategies to mitigate uncontrolled proliferation of gene-modified cells include… read more here.
Keywords: suicide gene; cell; safety; caspase ... See more keywords
Polycondensed Peptide Carriers Modified with Cyclic RGD Ligand for Targeted Suicide Gene Delivery to Uterine Fibroid Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031164
Abstract: Suicide gene therapy was suggested as a possible strategy for the treatment of uterine fibroids (UFs), which are the most common benign tumors inwomen of reproductive age. For successful suicide gene therapy, DNAtherapeutics should be… read more here.
Keywords: peptide carriers; gene delivery; suicide gene; ligand ... See more keywords