Unraveling the Abnormal Molecular Mechanism of Suicide Inhibition of Cytochrome P450 3A4
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.2c01035
Abstract: Suicide inhibition of the CYP3A4 enzyme by a drug inactivates the enzyme in the drug biotransformation process and often shows safety concerns about the drug. Despite extensive experimental studies, the abnormal molecular mechanism of a… read more here.
Keywords: suicide inhibition; abnormal molecular; molecular mechanism; mechanism suicide ... See more keywords
Synthesis of Fucose Derivatives with Thiol Motifs towards Suicide Inhibition of Helicobacter pylori
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DOI: 10.3390/molecules25184281
Abstract: The syntheses of six thiol-exhibiting monosaccharides towards suicide inhibition of Helicobacter pylori are reported. Blood group Antigen Binding Adhesin (BabA), a bacterial membrane-bound lectin, binds to human ABO and Lewis b blood group structures displayed… read more here.
Keywords: inhibition helicobacter; suicide inhibition; thiol motifs; helicobacter pylori ... See more keywords