1293. Sulbactam-durlobactam is active against recent, multi-drug resistant Acinetobacter baumannii clinical isolates from the Middle East
Sign Up to like & getrecommendations! Published in 2020 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofaa439.1476
Abstract: The incidence of infections caused by multidrug-resistant (MDR) Acinetobacter baumannii (Ab) is increasing at an alarming rate in certain regions of the world, including the Middle East. Sulbactam (SUL) has intrinsic antibacterial activity against Ab;… read more here.
Keywords: sul dur; middle east; clinical isolates; sulbactam ... See more keywords
Efficacy and safety of cefoperazone-sulbactam in empiric therapy for febrile neutropenia
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DOI: 10.1097/md.0000000000019321
Abstract: Supplemental Digital Content is available in the text Abstract Purpose: This meta-analysis assessed the clinical efficacy and safety of cefoperazone-sulbactam for empiric therapy febrile neutropenia. Methods: The PubMed, Web of Science, EBSCO, Cochrane Library, Ovid… read more here.
Keywords: febrile neutropenia; cefoperazone sulbactam; sulbactam;
Kinetics of Sulbactam Hydrolysis by β-Lactamases, and Kinetics of β-Lactamase Inhibition by Sulbactam
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DOI: 10.1128/aac.01612-17
Abstract: ABSTRACT Sulbactam is one of four β-lactamase inhibitors in current clinical use to counteract drug resistance caused by degradation of β-lactam antibiotics by these bacterial enzymes. As a β-lactam itself, sulbactam is susceptible to degradation… read more here.
Keywords: class; inhibition; sulbactam hydrolysis; kinetics sulbactam ... See more keywords
Probiotic Lactobacillus casei Shirota improves efficacy of amoxicillin-sulbactam against childhood fast breathing pneumonia in a randomized placebo-controlled double blind clinical study
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DOI: 10.3164/jcbn.17-117
Abstract: The aim of the present study was to investigate the efficacy of oral administration of probiotic Lactobacillus casei Shirota and amoxicillin-sulbactam in treating childhood fast breathing pneumonia. 518 children diagnosed of fast breathing pneumonia were… read more here.
Keywords: lactobacillus casei; casei shirota; amoxicillin sulbactam; fast breathing ... See more keywords
Zidebactam restores sulbactam susceptibility against carbapenem-resistant Acinetobacter baumannii isolates
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DOI: 10.3389/fcimb.2022.918868
Abstract: Carbapenems are commonly used to treat infections caused by multidrug-resistant (MDR) bacteria. Unfortunately, carbapenem resistance is increasingly reported in many gram-negative bacteria, especially Acinetobacter baumannii. Diazabicyclooctane (DBO) β-lactamase inhibitors, such as avibactam (AVI), when combined… read more here.
Keywords: sulbactam; zidebactam; combination; sulbactam susceptibility ... See more keywords
Effects of amikacin, polymyxin-B, and sulbactam combination on the pharmacodynamic indices of mutant selection against multi-drug resistant Acinetobacter baumannii
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.1013939
Abstract: Amikacin and polymyxins as monotherapies are ineffective against multidrug-resistant Acinetobacter baumannii at the clinical dose. When polymyxins, aminoglycosides, and sulbactam are co-administered, the combinations exhibit in vitro synergistic activities. The minimum inhibitory concentration (MIC) and… read more here.
Keywords: sulbactam; amikacin polymyxin; concentration; drug ... See more keywords