Sulfatase-2 from Cancer Associated Fibroblasts: An Environmental Target for Hepatocellular Carcinoma?
Sign Up to like & getrecommendations! Published in 2022 at "Liver Cancer"
DOI: 10.1159/000525375
Abstract: Introduction: Heparin sulphate proteoglycans in the liver tumour microenvironment (TME) are key regulators of cell signalling, modulated by sulfatase-2 (SULF2). SULF2 overexpression occurs in hepatocellular carcinoma (HCC). Our aims were to define the nature and… read more here.
Keywords: hepatocellular carcinoma; hcc; sulf2; associated fibroblasts ... See more keywords
SULF2 promotes tumorigenesis and inhibits apoptosis of cervical cancer cells through the ERK/AKT signaling pathway
Sign Up to like & getrecommendations! Published in 2020 at "Brazilian Journal of Medical and Biological Research"
DOI: 10.1590/1414-431x20198901
Abstract: The objective of this study was to explore the role of the SULF2-mediated ERK/AKT signaling pathway in cervical cancer. SULF2 expression was detected in tumor tissues and tumor-adjacent normal tissues from cervical cancer patients. HeLa… read more here.
Keywords: sulf2; erk akt; akt signaling; group ... See more keywords
Sulfatase-2 Regulates Liver Fibrosis through the TGF-β Signaling Pathway
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13215279
Abstract: Simple Summary Liver fibrosis and/or cirrhosis is a major risk factor for hepatocellular carcinoma. Hepatic Fibrogenesis is the result of an excessive production and deposition of extracellular matrix by hepatic myofibroblasts, which are primarily formed… read more here.
Keywords: sulf2; fibrosis; sulfatase; liver fibrosis ... See more keywords