The transmission-blocking effects of antimalarial drugs revisited: fitness costs and sporontocidal effects of artesunate and sulfadoxine-pyrimethamine.
Sign Up to like & getrecommendations! Published in 2021 at "International journal for parasitology"
DOI: 10.1016/j.ijpara.2020.09.012
Abstract: Assays used to evaluate the transmission-blocking activity of antimalarial drugs are largely focused on their potential to inhibit or reduce the infectivity of gametocytes, the blood stages of the parasite that are responsible for the… read more here.
Keywords: transmission; artesunate sulfadoxine; sulfadoxine pyrimethamine; blood ... See more keywords
Widespread resistance mutations to sulfadoxine-pyrimethamine in malaria parasites imported to China from Central and Western Africa
Sign Up to like & getrecommendations! Published in 2019 at "International Journal for Parasitology: Drugs and Drug Resistance"
DOI: 10.1016/j.ijpddr.2019.11.002
Abstract: Background Imported cases of infectious disease provide invaluable information about epidemiological conditions abroad, and should guide treatment decisions at home and abroad. Here, we examined cases of malaria imported from Africa to China for mutations… read more here.
Keywords: western africa; sulfadoxine pyrimethamine; resistance; first time ... See more keywords
Pregnancy and malaria: the perfect storm
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Infectious Diseases"
DOI: 10.1097/qco.0000000000000859
Abstract: Purpose of review Malaria in pregnancy continues to exert a toll on pregnant women and their offspring. Recent findings The burden of Plasmodium falciparum infection is especially large in Africa, and new data show lasting… read more here.
Keywords: infection; first trimester; pregnancy malaria; pregnancy ... See more keywords
Molecular Markers of Sulfadoxine-Pyrimethamine Resistance in Samples from Children with Uncomplicated Plasmodium falciparum at Three Sites in Angola in 2019
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DOI: 10.1128/aac.01601-22
Abstract: Sulfadoxine-pyrimethamine (SP) is used for prevention of malaria in pregnant women in Angola. We sequenced the Plasmodium falciparum dihydrofolate reductase (pfdhfr) and dihydropteroate synthase (pfdhps) genes, implicated in SP resistance, in samples collected during a… read more here.
Keywords: plasmodium falciparum; resistance samples; resistance; sulfadoxine pyrimethamine ... See more keywords
Detection of Falsified Antimalarial Sulfadoxine-Pyrimethamine and Dihydroartemisinin-Piperaquine Drugs Using a Low-Cost Handheld Near-Infrared Spectrometer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Analytical Methods in Chemistry"
DOI: 10.1155/2022/5335936
Abstract: Falsified drugs are of serious concern to public health worldwide, particularly for developing countries where quality control of drugs is inefficient. In law enforcement against such fake medicines, there is a need to develop reliable,… read more here.
Keywords: dihydroartemisinin piperaquine; near infrared; sulfadoxine pyrimethamine; low cost ... See more keywords
Occurrence of septuple and elevated Pfdhfr-Pfdhps quintuple mutations in a general population threatens the use of sulfadoxine-pyrimethamine for malaria prevention during pregnancy in eastern-coast of Tanzania
Sign Up to like & getrecommendations! Published in 2020 at "BMC Infectious Diseases"
DOI: 10.1186/s12879-020-05253-7
Abstract: Plasmodium falciparum dihydrofolate reductase (Pfdhfr) and dihydropteroate synthetase (Pfdhps) mutations compromise the effectiveness of sulfadoxine-pyrimethamine (SP) for treatment of uncomplicated malaria, and are likely to impair the efficiency of intermittent preventive treatment during pregnancy (IPTp).… read more here.
Keywords: pfdhfr pfdhps; pfdhps; sulfadoxine pyrimethamine; pfdhfr ... See more keywords
Origins and spread of novel genetic variants of sulfadoxine–pyrimethamine resistance in Plasmodium falciparum isolates in Indonesia
Sign Up to like & getrecommendations! Published in 2018 at "Malaria Journal"
DOI: 10.1186/s12936-018-2597-6
Abstract: BackgroundWhile malaria incidence in Indonesia has decreased threefold in the last decade, more than 200,000 cases were reported in 2016. Different endemicity of Plasmodium falciparum malaria among several islands in Indonesia has been recognized and… read more here.
Keywords: pfdhps; plasmodium falciparum; resistance; sulfadoxine pyrimethamine ... See more keywords
Prevalence of molecular markers of sulfadoxine–pyrimethamine and artemisinin resistance in Plasmodium falciparum from Pakistan
Sign Up to like & getrecommendations! Published in 2018 at "Malaria Journal"
DOI: 10.1186/s12936-018-2620-y
Abstract: BackgroundIn Pakistan, artesunate (AS) in combination with sulfadoxine–pyrimethamine (SP) is the recommended treatment for uncomplicated Plasmodium falciparum malaria. Monitoring molecular markers of anti-malarial drug resistance is crucial for early detection and containment of parasite resistance… read more here.
Keywords: falciparum; prevalence; artemisinin resistance; molecular markers ... See more keywords
Determinants of intermittent preventive treatment with sulfadoxine–pyrimethamine in pregnant women (IPTp-SP) in Mali, a household survey
Sign Up to like & getrecommendations! Published in 2021 at "Malaria Journal"
DOI: 10.1186/s12936-021-03764-5
Abstract: Background In malaria endemic regions, intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) is recommended for all pregnant women during prenatal consultation, from the fourth month of pregnancy up to the time of delivery. The Government of… read more here.
Keywords: iptp; intermittent preventive; sulfadoxine pyrimethamine; treatment sulfadoxine ... See more keywords
Spatiotemporal spread of Plasmodium falciparum mutations for resistance to sulfadoxine-pyrimethamine across Africa, 1990–2020
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1010317
Abstract: Background Sulfadoxine-pyrimethamine (SP) is recommended in Africa in several antimalarial preventive regimens including Intermittent Preventive Treatment in pregnant women (IPTp), Intermittent Preventive Treatment in infants (IPTi) and Seasonal Malaria Chemoprevention (SMC). The effectiveness of SP-based… read more here.
Keywords: plasmodium falciparum; africa; prevalence; sulfadoxine pyrimethamine ... See more keywords