Design and synthesis of 3-benzylaminocoumarin-7-O-sulfamate derivatives as steroid sulfatase inhibitors.
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DOI: 10.1016/j.bioorg.2020.103618
Abstract: Steroid sulfatase (STS) is a sulfatase enzyme that catalyzes the conversion of sulfated steroid precursors to free steroid. The inhibition of STS could abate estrogenic steroids that stimulate the proliferation and development of breast cancer,… read more here.
Keywords: design synthesis; sulfamate derivatives; benzylaminocoumarin sulfamate; steroid sulfatase ... See more keywords