Design, synthesis and biological evaluation of 2-((4-sulfamoylphenyl)amino)-pyrrolo[2,3-d]pyrimidine derivatives as CDK inhibitors
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DOI: 10.1080/14756366.2023.2169282
Abstract: Abstract To explore the potential use of CDK inhibitors in pancreatic ductal adenocarcinoma (PDAC) therapy, a series of novel 2-((4-sulfamoylphenyl)amino)-pyrrolo[2,3-d]pyrimidine derivatives was designed, synthesised, and investigated for inhibition on both CDK kinase activity and cellular… read more here.
Keywords: sulfamoylphenyl amino; cdk inhibitors; pyrrolo pyrimidine; pyrimidine derivatives ... See more keywords