CISD2 inhibition overcomes resistance to sulfasalazine-induced ferroptotic cell death in head and neck cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.06.018
Abstract: Sulfasalazine has been repurposed to induce ferroptotic cancer cell death via inhibition of xc--cystine/glutamate antiporter (xCT). However, cancer cells are capable of developing mechanisms to evade cell death. Therefore, we sought to determine the molecular… read more here.
Keywords: cancer; sulfasalazine; inhibition; cell death ... See more keywords
Host-guest chemistry of the sulfasalazine-β-cyclodextrin inclusion complex
Sign Up to like & getrecommendations! Published in 2021 at "Tetrahedron"
DOI: 10.1016/j.tet.2021.132052
Abstract: ABSTRACT Sulfasalazine (SLZ) is an azo drug used for the treatment of rheumatoid arthritis and ulcerative colitis. Its limited water solubility results into low permeability and bioavailability leading to higher daily recommended doses and greater… read more here.
Keywords: spectroscopy; sulfasalazine; host guest; chemistry ... See more keywords
Effects of sulfasalazine in axial spondyloarthritis on COVID-19 outcomes: real-life data from a single center.
Sign Up to like & getrecommendations! Published in 2022 at "Immunopharmacology and immunotoxicology"
DOI: 10.1080/08923973.2022.2160729
Abstract: INTRODUCTION Compared to biological agents, little is known about the impact of sulfasalazine therapy on COVID-19 outcomes in patients with Axial Spondyloarthritis (AxSpA). Therefore, we aimed to evaluate the COVID-19 severity in AxSpAs receiving sulfasalazine… read more here.
Keywords: covid outcomes; sulfasalazine; axial spondyloarthritis; covid ... See more keywords
The sFlt-1 to PlGF Ratio in Pregnant Women with Rheumatoid Arthritis: Impact of Disease Activity and Sulfasalazine Use.
Sign Up to like & getrecommendations! Published in 2021 at "Rheumatology"
DOI: 10.1093/rheumatology/keab372
Abstract: OBJECTIVES An elevated sFlt-1/PlGF-ratio has been validated as a significant predictor of preeclampsia, but has not been established in women with rheumatoid arthritis (RA). We explored whether the sFlt-1/PlGF-ratio could be altered due to disease… read more here.
Keywords: sulfasalazine; plgf; sflt plgf; disease activity ... See more keywords
In a cohort of individuals with type 2 diabetes using the drug sulfasalazine, HbA1c lowering is associated with haematological changes
Sign Up to like & getrecommendations! Published in 2020 at "Diabetic Medicine"
DOI: 10.1111/dme.14463
Abstract: Several small studies indicate the sulphonamide component of the drug sulfasalazine lowers HbA1c. We investigated reduction of HbA1c following incident prescription of sulfasalazine and related aminosalicylates, lacking the sulphonamide group, in an observational cohort. read more here.
Keywords: individuals type; sulfasalazine; cohort individuals; hba1c ... See more keywords
Sulfasalazine‐induced myopathy in a patient with an acute spondyloarthritis
Sign Up to like & getrecommendations! Published in 2022 at "Internal Medicine Journal"
DOI: 10.1111/imj.15654
Abstract: A 26-year-old Filipino man presented to his rheumatologist with symptoms of weakness in his lower limbs after noticing that activities such as running and walking up stairs had become quite difficult. He had not performed… read more here.
Keywords: sulfasalazine induced; patient; sulfasalazine; acute spondyloarthritis ... See more keywords
Combination Immunotherapy with Passive Antibody and Sulfasalazine Accelerates Fungal Clearance and Promotes the Resolution of Pneumocystis-Associated Immunopathogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Infection and Immunity"
DOI: 10.1128/iai.00640-19
Abstract: The pulmonary immune response protects healthy individuals against Pneumocystis pneumonia (PcP). However, the immune response also drives immunopathogenesis in patients who develop severe PcP, and it is generally accepted that optimal treatment requires combination strategies… read more here.
Keywords: antibody sulfasalazine; pneumocystis; pcp; sulfasalazine ... See more keywords
Management of haemolysis-induced hyperkalaemia in an extremely low birthweight infant exposed to maternal sulfasalazine
Sign Up to like & getrecommendations! Published in 2025 at "BMJ Case Reports"
DOI: 10.1136/bcr-2024-262380
Abstract: Sulfasalazine is a non-specific immunomodulator with haemolytic anaemia as a known side effect that crosses the placenta. We present a preterm neonate with cardiac arrhythmia secondary to hyperkalaemia in the setting of maternal sulfasalazine therapy.… read more here.
Keywords: sulfasalazine; hyperkalaemia; haemolysis induced; infant ... See more keywords
Protective antioxidative and anti-inflammatory actions of β-caryophyllene against sulfasalazine-induced nephrotoxicity in rat
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Biology and Medicine"
DOI: 10.1177/15353702211073804
Abstract: The pathogenesis of sulfasalazine (SFZ)-induced nephrotoxicity is unclear. Moreover, there are no reports on the protective effects of β-caryophyllene (BCP) against SFZ-induced renal injury. Hence, in this study, we measured several oxidative stress and inflammatory… read more here.
Keywords: sulfasalazine; factor; anti inflammatory; antioxidative anti ... See more keywords
Integration of Design of Experiments for the Development and Evaluation of Sulfasalazine Loaded Hybrid Albumin Chitosan Based Polymeric Nanocarriers
Sign Up to like & getrecommendations! Published in 2025 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-025-03190-9
Abstract: Sulfasalazine is a sepiapterin reductase and System x − c inhibitor with anti-neuroblastoma activity. The objective was to develop cellular redox glutathione stimuli-responsive Sulfasalazine-loaded albumin-chitosan hybrid nanocarriers with a target profile of read more here.
Keywords: sulfasalazine; glutathione; drug; albumin chitosan ... See more keywords
Sulfasalazine prevents lung injury due to intra-abdominal sepsis in rats: possible role of Nrf2 and angiopoietin-2
Sign Up to like & getrecommendations! Published in 2023 at "Brazilian Journal of Medical and Biological Research"
DOI: 10.1590/1414-431x2023e12698
Abstract: This study aimed to investigate the effect of sulfasalazine in preventing and treating intra-abdominal sepsis-induced acute respiratory distress syndrome (ARDS) in a rat model. Forty male Wistar albino rats were used. The rats were randomly… read more here.
Keywords: sepsis; sulfasalazine; group; group fip ... See more keywords