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Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.06.018
Abstract: Sulfasalazine has been repurposed to induce ferroptotic cancer cell death via inhibition of xc--cystine/glutamate antiporter (xCT). However, cancer cells are capable of developing mechanisms to evade cell death. Therefore, we sought to determine the molecular…
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Keywords:
cancer;
sulfasalazine;
inhibition;
cell death ... See more keywords
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Published in 2021 at "Tetrahedron"
DOI: 10.1016/j.tet.2021.132052
Abstract: ABSTRACT Sulfasalazine (SLZ) is an azo drug used for the treatment of rheumatoid arthritis and ulcerative colitis. Its limited water solubility results into low permeability and bioavailability leading to higher daily recommended doses and greater…
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Keywords:
spectroscopy;
sulfasalazine;
host guest;
chemistry ... See more keywords
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Published in 2022 at "Immunopharmacology and immunotoxicology"
DOI: 10.1080/08923973.2022.2160729
Abstract: INTRODUCTION Compared to biological agents, little is known about the impact of sulfasalazine therapy on COVID-19 outcomes in patients with Axial Spondyloarthritis (AxSpA). Therefore, we aimed to evaluate the COVID-19 severity in AxSpAs receiving sulfasalazine…
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Keywords:
covid outcomes;
sulfasalazine;
axial spondyloarthritis;
covid ... See more keywords
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Published in 2021 at "Rheumatology"
DOI: 10.1093/rheumatology/keab372
Abstract: OBJECTIVES An elevated sFlt-1/PlGF-ratio has been validated as a significant predictor of preeclampsia, but has not been established in women with rheumatoid arthritis (RA). We explored whether the sFlt-1/PlGF-ratio could be altered due to disease…
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Keywords:
sulfasalazine;
plgf;
sflt plgf;
disease activity ... See more keywords
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Published in 2020 at "Diabetic Medicine"
DOI: 10.1111/dme.14463
Abstract: Several small studies indicate the sulphonamide component of the drug sulfasalazine lowers HbA1c. We investigated reduction of HbA1c following incident prescription of sulfasalazine and related aminosalicylates, lacking the sulphonamide group, in an observational cohort.
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Keywords:
individuals type;
sulfasalazine;
cohort individuals;
hba1c ... See more keywords
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Published in 2022 at "Internal Medicine Journal"
DOI: 10.1111/imj.15654
Abstract: A 26-year-old Filipino man presented to his rheumatologist with symptoms of weakness in his lower limbs after noticing that activities such as running and walking up stairs had become quite difficult. He had not performed…
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Keywords:
sulfasalazine induced;
patient;
sulfasalazine;
acute spondyloarthritis ... See more keywords
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Published in 2019 at "Infection and Immunity"
DOI: 10.1128/iai.00640-19
Abstract: The pulmonary immune response protects healthy individuals against Pneumocystis pneumonia (PcP). However, the immune response also drives immunopathogenesis in patients who develop severe PcP, and it is generally accepted that optimal treatment requires combination strategies…
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Keywords:
antibody sulfasalazine;
pneumocystis;
pcp;
sulfasalazine ... See more keywords
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Published in 2022 at "Experimental Biology and Medicine"
DOI: 10.1177/15353702211073804
Abstract: The pathogenesis of sulfasalazine (SFZ)-induced nephrotoxicity is unclear. Moreover, there are no reports on the protective effects of β-caryophyllene (BCP) against SFZ-induced renal injury. Hence, in this study, we measured several oxidative stress and inflammatory…
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Keywords:
sulfasalazine;
factor;
anti inflammatory;
antioxidative anti ... See more keywords
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Published in 2023 at "Brazilian Journal of Medical and Biological Research"
DOI: 10.1590/1414-431x2023e12698
Abstract: This study aimed to investigate the effect of sulfasalazine in preventing and treating intra-abdominal sepsis-induced acute respiratory distress syndrome (ARDS) in a rat model. Forty male Wistar albino rats were used. The rats were randomly…
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Keywords:
sepsis;
sulfasalazine;
group;
group fip ... See more keywords
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Published in 2020 at "Tropical Journal of Pharmaceutical Research"
DOI: 10.4314/tjpr.v19i2.26
Abstract: Purpose: To compare, in a retrospective study, the effects and safety profiles of Tripterygii totorum and sulfasalazine in patients with rheumatoid arthritis (RA) following 24 weeks of treatment. Methods: RA patients (n = 164) who…
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Keywords:
sulfasalazine;
totorum sulfasalazine;
study;
acr response ... See more keywords
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Published in 2022 at "International journal of clinical pharmacology and therapeutics"
DOI: 10.5414/cp204120
Abstract: OBJECTIVES Sulfasalazine has been widely used in treatment of rheumatoid arthritis and spondyloarthritis. This study aims to assess persistence with sulfasalazine and also frequency and severity of adverse drug reactions (ADRs) encountered with this very…
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Keywords:
arthritis spondyloarthritis;
sulfasalazine;
rheumatoid arthritis;
drug ... See more keywords