Molecular Basis for Enzymatic Aziridine Formation via Sulfate Elimination.
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DOI: 10.1021/jacs.2c07243
Abstract: Natural products containing an aziridine ring, such as mitomycin C and azinomycin B, exhibit antitumor activities by alkylating DNA via their aziridine rings; however, the biosynthetic mechanisms underlying the formation of these rings have not… read more here.
Keywords: via sulfate; aziridine ring; aziridine; formation ... See more keywords