Structural and conformational studies of the heparan sulfate mimetic PI-88
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DOI: 10.1093/glycob/cwy068
Abstract: The heparan sulfate mimetic PI-88 is a complex mixture of sulfated oligosaccharides with anti-metastatic and anti-angiogenic activity due to its potent inhibition of heparanase and heparan sulfate-dependent angiogenic growth factors. It was recently in Phase… read more here.
Keywords: conformational studies; sulfate mimetic; heparan sulfate; studies heparan ... See more keywords
The Heparan Sulfate Mimetic PG545 Modulates T Cell Responses and Prevents Delayed-Type Hypersensitivity
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DOI: 10.3389/fimmu.2020.00132
Abstract: The heparan sulfate mimetic PG545 (pixatimod) is under evaluation as an inhibitor of angiogenesis and metastasis including in human clinical trials. We have examined the effects of PG545 on lymphocyte phenotypes and function. We report… read more here.
Keywords: pg545; sulfate mimetic; heparan sulfate; type hypersensitivity ... See more keywords
Synthetic Heparan Sulfate Mimetic Polymer Enhances Corneal Nerve Regeneration and Wound Healing after Experimental Laser Ablation Injury in Mice
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DOI: 10.3390/polym14224921
Abstract: (1) Background: Abnormal corneal wound healing compromises visual acuity and can lead to neuropathic pain. Conventional treatments usually fail to restore the injured corneal tissue. In this study, we evaluated the effectiveness of a synthetic… read more here.
Keywords: wound healing; laser; heparan sulfate; sulfate mimetic ... See more keywords