Select neurotrophins promote oligodendrocyte progenitor cell process outgrowth in the presence of chondroitin sulfate proteoglycans
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24780
Abstract: Axonal damage and the subsequent interruption of intact neuronal pathways in the spinal cord are largely responsible for the loss of motor function after injury. Further exacerbating this loss is the demyelination of neighboring uninjured… read more here.
Keywords: chondroitin sulfate; oligodendrocyte progenitor; sulfate proteoglycans; neurotrophic factor ... See more keywords
Chondroitin sulfate proteoglycans from salmon nasal cartilage inhibit angiogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2016.11.009
Abstract: Because cartilage lacks nerves, blood vessels, and lymphatic vessels, it is thought to contain factors that inhibit the growth and development of those tissues. Chondroitin sulfate proteoglycans (CSPGs) are a major extracellular component in cartilage.… read more here.
Keywords: nasal cartilage; salmon nasal; chondroitin sulfate; sulfate proteoglycans ... See more keywords
Blockade of chondroitin sulfate proteoglycans-induced axonal growth inhibition by LOTUS
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2017.05.034
Abstract: Chondroitin sulfate proteoglycans (CSPGs) are axon growth inhibitors in the glial scar, and restrict axon regeneration following damage to the adult mammalian central nervous system. CSPGs have recently been identified as functional ligands for Nogo… read more here.
Keywords: lotus; chondroitin sulfate; growth inhibition; sulfate proteoglycans ... See more keywords
Infection and transmission of SARS-CoV-2 depends on heparan sulfate proteoglycans
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Immunology"
DOI: 10.1101/2020.08.18.255810
Abstract: The current pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and outbreaks of new variants highlight the need for preventive treatments. Here we identified heparan sulfate proteoglycans as attachment receptors for SARS CoV-2. Notably,… read more here.
Keywords: infection transmission; heparan sulfate; sulfate proteoglycans; sars cov ... See more keywords
Chondroitin Sulfate Proteoglycans Are De Facto Cellular Receptors for Human Papillomavirus 16 under High Serum Conditions
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.01857-21
Abstract: Heparan sulfate proteoglycans (HSPGs) have previously been identified as primary attachment factors for the initial binding of human papillomaviruses (HPVs) prior to infection. Here, we demonstrate that in vitro, HPV binding to HSPGs is strongly… read more here.
Keywords: serum; infection; hpv; chondroitin sulfate ... See more keywords
Unacylated ghrelin binds heparan-sulfate proteoglycans which modulate its function.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular endocrinology"
DOI: 10.1530/jme-20-0286
Abstract: Acylated ghrelin (AG) is a gut-derived peptide with growth hormone secretagogue (GHS), orexigenic and other physiological activities mediated by GHS receptor-1a (GHSR). Ghrelin occurs in unacylated form (UAG) with activities opposing AG, although its mechanism… read more here.
Keywords: heparan sulfate; sulfate proteoglycans; receptor; cell ... See more keywords
Roles of Chondroitin Sulfate Proteoglycans as Regulators of Skeletal Development
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.745372
Abstract: The extracellular matrix (ECM) is critically important for most cellular processes including differentiation, morphogenesis, growth, survival and regeneration. The interplay between cells and the ECM often involves bidirectional signaling between ECM components and small molecules,… read more here.
Keywords: proteoglycans regulators; roles chondroitin; development; chondroitin sulfate ... See more keywords
Bioinformatics analysis identifies heparan sulfate proteoglycans acting as different progress subtypes of biliary atresia
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2023.1065521
Abstract: Background Biliary atresia (BA) is a life-threatening disorder, which is characterized by the obliteration of biliary tracts. Heparan sulfate proteoglycans (HSPGs) are important regulators in liver diseases. Whether HSPGs participate in the development of BA… read more here.
Keywords: heparan sulfate; biliary atresia; expression; analysis ... See more keywords
Heparan Sulfate Proteoglycans in Tauopathy
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DOI: 10.3390/biom12121792
Abstract: Tauopathies are a class of neurodegenerative diseases, including Alzheimer’s disease, and are characterized by intraneuronal tau inclusion in the brain and the patient’s cognitive decline with obscure pathogenesis. Heparan sulfate proteoglycans, a major type of… read more here.
Keywords: proteoglycans tauopathy; heparan sulfate; sulfate proteoglycans; tau ... See more keywords
The Tissue Factor Pathway in Cancer: Overview and Role of Heparan Sulfate Proteoglycans
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DOI: 10.3390/cancers15051524
Abstract: Simple Summary Tissue factor is a protein that is important for the regulation of blood coagulation. New research has highlighted the important roles of tissue factor in cancer. This review summarizes recent work that shows… read more here.
Keywords: heparan sulfate; tissue factor; factor; sulfate proteoglycans ... See more keywords
Heparan Sulfate Proteoglycans and Viral Attachment: True Receptors or Adaptation Bias?
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DOI: 10.3390/v11070596
Abstract: Heparan sulfate proteoglycans (HSPG) are composed of unbranched, negatively charged heparan sulfate (HS) polysaccharides attached to a variety of cell surface or extracellular matrix proteins. Widely expressed, they mediate many biological activities, including angiogenesis, blood… read more here.
Keywords: sulfate; proteoglycans viral; heparan sulfate; sulfate proteoglycans ... See more keywords