Mitoxantrone modulates a heparan sulfate-spike complex to inhibit SARS-CoV-2 infection
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DOI: 10.1038/s41598-022-10293-x
Abstract: Spike-mediated entry of SARS-CoV-2 into human airway epithelial cells is an attractive therapeutic target for COVID-19. In addition to protein receptors, the SARS-CoV-2 spike (S) protein also interacts with heparan sulfate, a negatively charged glycosaminoglycan… read more here.
Keywords: mitoxantrone; sulfate spike; heparan sulfate; sars cov ... See more keywords