The effects of sulfated hyaluronan in breast, lung and colorectal carcinoma and monocytes/macrophages cells: Its role in angiogenesis and tumor progression.
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DOI: 10.1002/iub.2604
Abstract: Hyaluronan (HA) is a component of the extracellular matrix (ECM) it is the main non-sulfated glycosaminoglycan able to modulate cell behavior in the healthy and tumor context. Sulfated hyaluronan (sHA) is a biomaterial derived from… read more here.
Keywords: tumor; lung colorectal; monocytes macrophages; sulfated hyaluronan ... See more keywords
Sulfated hyaluronan attenuates inflammatory signaling pathways in macrophages involving induction of antioxidants
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DOI: 10.1002/pmic.201700082
Abstract: It is well recognized that high molecular weight hyaluronan (H‐HA) exerts potent anti‐inflammatory effects while its fragmentation into low molecular weight HA (L‐HA) is discussed to promote inflammation. Chemical modification of HA with sulfate groups… read more here.
Keywords: anti inflammatory; hyaluronan attenuates; sulfated hyaluronan; inflammatory ... See more keywords
Increased pore size of scaffolds improves coating efficiency with sulfated hyaluronan and mineralization capacity of osteoblasts
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DOI: 10.1186/s40824-019-0172-z
Abstract: BackgroundDelayed bone regeneration of fractures in osteoporosis patients or of critical-size bone defects after tumor resection are a major medical and socio-economic challenge. Therefore, the development of more effective and osteoinductive biomaterials is crucial.MethodsWe examined… read more here.
Keywords: sha3; pore size; bone; size ... See more keywords
Sulfated Hyaluronan Binds to Heparanase and Blocks Its Enzymatic and Cellular Actions in Carcinoma Cells
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DOI: 10.3390/ijms23095055
Abstract: We examined whether sulfated hyaluronan exerts inhibitory effects on enzymatic and biological actions of heparanase, a sole endo-beta-glucuronidase implicated in cancer malignancy and inflammation. Degradation of heparan sulfate by human and mouse heparanase was inhibited… read more here.
Keywords: enzymatic cellular; cellular actions; heparanase; sulfated hyaluronan ... See more keywords