Reactions of sulfenic acids with amines, thiols, and thiolates studied by quantum chemical calculations
Sign Up to like & getrecommendations! Published in 2020 at "Computational and Theoretical Chemistry"
DOI: 10.1016/j.comptc.2020.112979
Abstract: Abstract Biological sensor molecules for oxidative stress often rely on the oxidation of thiols to sulfenic acid intermediates. How this transformation induces a physiological response often relies on the fate of sulfenic acid. Sulfenic acids… read more here.
Keywords: acids amines; amines thiols; reactions sulfenic; thiols thiolates ... See more keywords
The microenvironment of the sulfenic acid of human serum albumin: In search of clues for explaining its spontaneous decay
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.015
Abstract: Human serum albumin (HSA) is the most abundant protein in plasma. It consists of a single, non-glycosylated polypeptide chain of 585 residues. Only one free cysteine, namely Cys34, is present in HSA structure. With a… read more here.
Keywords: hsa; human serum; acid; serum albumin ... See more keywords
New insights into the chemical behavior of S-oxide derivatives of thiocarbonyl-containing antitubercular drugs and the influence on their mechanisms of action and toxicity.
Sign Up to like & getrecommendations! Published in 2019 at "Annales pharmaceutiques francaises"
DOI: 10.1016/j.pharma.2018.11.004
Abstract: OBJECTIVES This work aims at getting more insights into the distinct behavior of S-oxide derivatives of thiocarbonyl-containing antitubercular drugs, in order to better understand their mechanism of action and toxicity. METHODS Computational calculation of relative… read more here.
Keywords: antitubercular drugs; action toxicity; sulfenic acid; oxide derivatives ... See more keywords
Detection of sulfenic acid in intact proteins by mass spectrometric techniques: application to serum samples
Sign Up to like & getrecommendations! Published in 2017 at "RSC Advances"
DOI: 10.1039/c7ra06241a
Abstract: Formation of cysteine sulfenic acid (SA) is considered a transient state of thiol oxidation in living organisms that can be either reduced back or continue to result in the formation of sulfinic and sulfonic acids.… read more here.
Keywords: detection; mass; serum; formation ... See more keywords