Structure‐guided identification of a selective sulfonamide‐based inhibitor targeting the human carbonic anhydrase VA isoform
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200383
Abstract: In recent years, multistep hybrid computational protocols have attracted attention for their application in the drug discovery of enzyme inhibitors. So far, there are large collections of human carbonic anhydrase (hCA) inhibitors, but only a… read more here.
Keywords: human carbonic; sulfonamide based; carbonic anhydrase; hca ... See more keywords
Examination of sulfonamide-based inhibitors of MMP3 using the conditioned media of invasive glioma cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2020.1715387
Abstract: Abstract Glioblastoma multiforme (GBM) is the deadliest and the most common primary malignant brain tumour. The median survival for patients with GBM is around one year due to the nature of glioma cells to diffusely… read more here.
Keywords: conditioned media; glioma; sulfonamide based; glioma cells ... See more keywords
Beneficial effects of sulfonamide-based gallates on osteoblasts in vitro
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DOI: 10.3892/mmr.2021.12152
Abstract: Following the publication of the above article, an interested reader drew to the authors' attention that three figures in their paper (namely Figs. 2, 4 and 5) appeared to feature panels containing overlapping data. The authors… read more here.
Keywords: medicine reports; medicine; sulfonamide based; molecular medicine ... See more keywords
Identification of sulfonamide-based butyrylcholinesterase inhibitors using machine learning.
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DOI: 10.4155/fmc-2021-0325
Abstract: Aim: This study reports the designing of BChE inhibitors through machine learning (ML), followed by in silico and in vitro evaluations. Methodology: ML technique was used to predict the virtual hit, and its derivatives were synthesized… read more here.
Keywords: machine; machine learning; butyrylcholinesterase inhibitors; based butyrylcholinesterase ... See more keywords