Synthesis and examination of 1,2,4‐triazine‐sulfonamide hybrids as potential inhibitory drugs: Inhibition effects on AChE and GST enzymes in silico and in vitro conditions
Sign Up to like & getrecommendations! Published in 2024 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202400182
Abstract: The crucial functions of acetylcholinesterase (AChE) in neurotransmission and glutathione S‐transferase (GST) in detoxification and cellular protection underscore their pivotal roles as key enzymes, essential for maintaining the integrity of neurological and cellular homeostasis. For… read more here.
Keywords: ache gst; effects ache; sulfonamide hybrids; triazine sulfonamide ... See more keywords
Efficient click reaction towards novel sulfonamide hybrids by molecular hybridization strategy as antiproliferative agents
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DOI: 10.1007/s12039-017-1415-y
Abstract: Abstract Twelve novel sulfonamide hybrids were designed by molecular hybridization strategy. The target sulfonamide hybrids were obtained in the click reaction of azide derivatives and commerciallly available alkynes. All sulfonamide hybrids were evaluated for their antiproliferative… read more here.
Keywords: click reaction; sulfonamide hybrids; molecular hybridization; novel sulfonamide ... See more keywords
Terminators or Guardians? Design, Synthesis, and Cytotoxicity Profiling of Chalcone-Sulfonamide Hybrids
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DOI: 10.1021/acsomega.2c07285
Abstract: With a “less is more” philosophy, a series of 15 chalcone-sulfonamide hybrids were designed anticipating synergistic anticancer activity. The aromatic sulfonamide moiety was included as a known direct inhibitor of carbonic anhydrase IX activity through… read more here.
Keywords: carbonic anhydrase; chalcone sulfonamide; activity; sulfonamide hybrids ... See more keywords
Synthesis, Carbonic Anhydrase II/IX/XII Inhibition, DFT, and Molecular Docking Studies of Hydrazide-Sulfonamide Hybrids of 4-Methylsalicyl- and Acyl-Substituted Hydrazide
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DOI: 10.1155/2022/5293349
Abstract: Carbonic anhydrases (CAs and EC 4.2.1.1) are the Zn2+ containing enzymes which catalyze the reversible hydration of CO2 to carbonate and proton. If they are not functioning properly, it would lead towards many diseases including… read more here.
Keywords: molecular docking; xii; carbonic anhydrase; hydrazide sulfonamide ... See more keywords
Design, synthesis, ADME prediction and pharmacological evaluation of novel benzimidazole-1,2,3-triazole-sulfonamide hybrids as antimicrobial and antiproliferative agents
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DOI: 10.1186/s13065-018-0479-1
Abstract: BackgroundNitrogen heterocyclic rings and sulfonamides have attracted attention of several researchers.ResultsA series of regioselective imidazole-based mono- and bis-1,4-disubstituted-1,2,3-triazole-sulfonamide conjugates 4a–f and 6a–f were designed and synthesized. The first step in the synthesis was a regioselective… read more here.
Keywords: antimicrobial antiproliferative; sulfonamide hybrids; evaluation; benzimidazole triazole ... See more keywords
Recent Advances on Biological Active Sulfonamide based Hybrid Compounds Part B: Two-Component Sulfonamide Hybrids.
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DOI: 10.2174/0929867329666220722143547
Abstract: Sulfonamide compounds, also known as sulfa drugs, are a significant class of synthetic bacteriostatic antimicrobials and were the primary source of therapy against bacterial infections before the introduction of penicillin in 1941. Hybridization of sulfonamides… read more here.
Keywords: component sulfonamide; sulfonamide; two component; sulfonamide hybrids ... See more keywords
The anticancer therapeutic potential of pyrimidine-sulfonamide hybrids.
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DOI: 10.4155/fmc-2024-0010
Abstract: Cancer as a devastating malignancy, seriously threatens human life and health, but most chemotherapeutics have long been criticized for unsatisfactory therapeutic efficacy due to drug resistance and severe off-target toxicity. Pyrimidines, including fused pyrimidines, are… read more here.
Keywords: hybrids anticancer; pyrimidine sulfonamide; sulfonamide hybrids; anticancer therapeutic ... See more keywords