Sulfonamide Inhibitors of β‐Catenin Signaling as Anticancer Agents with Different Output on c‐MYC
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DOI: 10.1002/cmdc.202000594
Abstract: The Wnt/β‐catenin pathway is often found deregulated in cancer. The aberrant accumulation of β‐catenin in the cell nucleus results in the development of various malignancies. Specific drugs against this signaling pathway for clinical treatments have… read more here.
Keywords: inhibitors catenin; anticancer agents; catenin signaling; sulfonamide inhibitors ... See more keywords
Sulfonamide Inhibitors of Human Carbonic Anhydrases Designed through a Three-Tails Approach: Improving Ligand/Isoform Matching and Selectivity of Action
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DOI: 10.1021/acs.jmedchem.0c00733
Abstract: The “tail approach” has become a milestone in human carbonic anhydrase inhibitor (hCAI) design for various therapeutics, including antiglaucoma agents. Besides the classical hydrophobic/hydrophilic division of hCAs active site, several subpockets have been identified at… read more here.
Keywords: human carbonic; inhibitors human; carbonic anhydrases; sulfonamide inhibitors ... See more keywords