Challenging breast cancer through novel sulfonamide-pyridine hybrids: design, synthesis, carbonic anhydrase IX inhibition and induction of apoptosis.
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DOI: 10.4155/fmc-2022-0197
Abstract: Background: Among the important key modulators of the tumor microenvironment and hypoxia is a family of enzymes named carbonic anhydrases. Herein, 11 novel sulfonamide-pyridine hybrids (2-12) were designed, synthesized and biologically evaluated for their potential… read more here.
Keywords: sulfonamide pyridine; pyridine hybrids; breast; breast cancer ... See more keywords