Development and validation of a sensitive method for alkyl sulfonate genotoxic impurities determination in drug substances using gas chromatography coupled to triple quadrupole mass spectrometry
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.12.044
Abstract: HighlightsQuantitative detection of 9 sulfonate esters by GC–MS‐MS simultaneously.The method gave extremely high sensitivity for 9 sulfonate esters compared to reported articles.LOQs for 9 sulfonate esters were within 0.10–1.05 ng mL−1.This method was successfully applied… read more here.
Keywords: alkyl; drug substances; method; drug ... See more keywords
Differentiation of Protonated Sulfonate Esters from Isomeric Sulfite Esters and Sulfones by Gas-Phase Ion-Molecule Reactions Followed by Diagnostic Collision-Activated Dissociation in Tandem Mass Spectrometry Experiments.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c00731
Abstract: Sulfonate esters, a class of potentially mutagenic drug impurities, are strictly regulated in pharmaceuticals. On the other hand, sulfite esters and sulfones, analogs of sulfonate esters, have limited safety concerns. However, previously developed analytical methods… read more here.
Keywords: sulfite esters; molecule; product ions; sulfonate esters ... See more keywords
Alkoxysulfonyl radical species: acquisition and transformation towards sulfonate esters through electrochemistry
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d2sc04027a
Abstract: Sulfonyl radical mediated processes have been considered as a powerful strategy for the construction of sulfonyl compounds. However, an efficient and high atom-economical radical approach to the synthesis of sulfonate esters is still rare, owing… read more here.
Keywords: alkoxysulfonyl radical; species acquisition; radical species; electrochemistry ... See more keywords
Divergent reactivities of 2-pyridyl sulfonate esters. Exceptionally mild access to alkyl bromides and 2-substituted pyridines
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DOI: 10.1139/cjc-2020-0510
Abstract: A series of 2- and 3-pyridyl sulfonate and tosylate esters of primary and secondary alcohols were synthesized and evaluated in the bromination reaction with MgBr2·Et2O. The greater coordinating ability of the 2-pyridyl sulfonate esters accounted… read more here.
Keywords: sulfonate esters; divergent reactivities; esters exceptionally; reactivities pyridyl ... See more keywords
Isoniazid Linked to Sulfonate Esters via Hydrazone Functionality: Design, Synthesis, and Evaluation of Antitubercular Activity
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15101301
Abstract: Isoniazid (INH) is one of the key molecules employed in the treatment of tuberculosis (TB), the most deadly infectious disease worldwide. However, the efficacy of this cornerstone drug has seriously decreased due to emerging INH-resistant… read more here.
Keywords: sih1 sih13; sulfonate esters; esters via; inh ... See more keywords