Transition Metal-Catalyzed Cross-Couplings of Benzylic Sulfone Derivatives.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical record"
DOI: 10.1002/tcr.202100210
Abstract: In recent years, the use of organosulfones as a new class of cross-coupling partner in transition-metal catalyzed reactions has undergone significant advancement. In this personal account, our recent investigations into desulfonylative cross-coupling reactions of benzylic… read more here.
Keywords: transition metal; sulfone derivatives; cross; metal catalyzed ... See more keywords
Discovery of Benzocyclic Sulfone Derivatives as Potent CXCR2 Antagonists for Cancer Immunotherapy.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01219
Abstract: Increasing evidence shows that the CXC chemokine receptor 2 (CXCR2) signaling pathway is essentially implicated in the recruitment of myeloid-derived suppressor cells (MDSCs) to the tumor microenvironment and leads to MDSC-mediated immune suppression. Therefore, CXCR2… read more here.
Keywords: potent cxcr2; benzocyclic sulfone; sulfone derivatives; cancer immunotherapy ... See more keywords